Detailed information of TA system TA294017

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 990770..991077
• Replicon: chromosome
• Accession: NZ_LT992435
• Organism: Staphylococcus aureus isolate 1549-SCV

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DYY96_RS05120
• Protein ID: WP_011447039.1
• Coordinates: 990901..991077 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	990770..990909 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DYY96_RS05075	986109..986369	+	261	WP_001791826.1	hypothetical protein	-
DYY96_RS05080	986422..986772	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
DYY96_RS05085	987457..987906	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
DYY96_RS05090	988001..988336	-	336	Protein_937	SH3 domain-containing protein	-
DYY96_RS05100	988986..989477	-	492	WP_000919350.1	staphylokinase	-
DYY96_RS05105	989668..990423	-	756	WP_000861038.1	CHAP domain-containing protein	-
DYY96_RS05110	990435..990689	-	255	WP_000611512.1	phage holin	-
DYY96_RS05115	990741..990848	+	108	WP_001791821.1	hypothetical protein	-
-	990770..990909	+	140	NuclAT_0	-	Antitoxin
-	990770..990909	+	140	NuclAT_0	-	Antitoxin
-	990770..990909	+	140	NuclAT_0	-	Antitoxin
-	990770..990909	+	140	NuclAT_0	-	Antitoxin
DYY96_RS05120	990901..991077	-	177	WP_011447039.1	putative holin-like toxin	Toxin
DYY96_RS05125	991227..991523	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
DYY96_RS05130	991581..991868	-	288	WP_001040261.1	hypothetical protein	-
DYY96_RS05135	991915..992067	-	153	WP_001153681.1	hypothetical protein	-
DYY96_RS05140	992057..995842	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	986422..1036704	50282

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T294017 WP_011447039.1 NZ_LT992435:c991077-990901 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294017 NZ_LT992435:990770-990909 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin