Detailed information of TA system TA294009

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 990764..991071
• Replicon: chromosome
• Accession: NZ_LT992434
• Organism: Staphylococcus aureus isolate 1549-WT

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DYY92_RS05120
• Protein ID: WP_011447039.1
• Coordinates: 990895..991071 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	990764..990903 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DYY92_RS05075	986103..986363	+	261	WP_001791826.1	hypothetical protein	-
DYY92_RS05080	986416..986766	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
DYY92_RS05085	987451..987900	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
DYY92_RS05090	987995..988330	-	336	Protein_936	SH3 domain-containing protein	-
DYY92_RS05100	988980..989471	-	492	WP_000919350.1	staphylokinase	-
DYY92_RS05105	989662..990417	-	756	WP_000861038.1	CHAP domain-containing protein	-
DYY92_RS05110	990429..990683	-	255	WP_000611512.1	phage holin	-
DYY92_RS05115	990735..990842	+	108	WP_001791821.1	hypothetical protein	-
-	990764..990903	+	140	NuclAT_0	-	Antitoxin
-	990764..990903	+	140	NuclAT_0	-	Antitoxin
-	990764..990903	+	140	NuclAT_0	-	Antitoxin
-	990764..990903	+	140	NuclAT_0	-	Antitoxin
DYY92_RS05120	990895..991071	-	177	WP_011447039.1	putative holin-like toxin	Toxin
DYY92_RS05125	991221..991517	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
DYY92_RS05130	991575..991862	-	288	WP_001040261.1	hypothetical protein	-
DYY92_RS05135	991909..992061	-	153	WP_001153681.1	hypothetical protein	-
DYY92_RS05140	992051..995836	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	986416..1036698	50282

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T294009 WP_011447039.1 NZ_LT992434:c991071-990895 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294009 NZ_LT992434:990764-990903 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin