Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2143225..2143955 Replicon chromosome
Accession NZ_LT991957
Organism Enterobacter cloacae complex sp. isolate C45

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DBR02_RS10720 Protein ID WP_107534330.1
Coordinates 2143225..2143539 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DBR02_RS10725 Protein ID WP_129741611.1
Coordinates 2143536..2143955 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBR02_RS10695 2138890..2139978 + 1089 WP_063868639.1 cellulase family glycosylhydrolase -
DBR02_RS10700 2139881..2141065 - 1185 WP_107535638.1 multidrug efflux MFS transporter EmrD -
DBR02_RS10705 2141241..2142074 - 834 WP_107534326.1 DMT family transporter -
DBR02_RS10710 2142137..2142583 - 447 WP_107534328.1 GNAT family N-acetyltransferase -
DBR02_RS10715 2142648..2142737 - 90 WP_017383683.1 type I toxin-antitoxin system toxin TisB -
DBR02_RS10720 2143225..2143539 + 315 WP_107534330.1 type II toxin-antitoxin system HigB family toxin Toxin
DBR02_RS10725 2143536..2143955 + 420 WP_129741611.1 helix-turn-helix domain-containing protein Antitoxin
DBR02_RS10730 2144102..2144200 + 99 WP_057979964.1 ilvB operon leader peptide IvbL -
DBR02_RS10735 2144307..2145995 + 1689 WP_107534332.1 acetolactate synthase large subunit -
DBR02_RS10740 2145999..2146286 + 288 WP_010426528.1 acetolactate synthase small subunit -
DBR02_RS10745 2146410..2147003 + 594 WP_003861054.1 transcriptional regulator UhpA -
DBR02_RS10750 2147000..2148505 + 1506 WP_107534333.1 signal transduction histidine-protein kinase/phosphatase UhpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(23-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-137)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12422.51 Da        Isoelectric Point: 10.0527

>T293995 WP_107534330.1 NZ_LT991957:2143225-2143539 [Enterobacter cloacae complex sp.]
MHLISMKAICEAVSQFPQYRDELLFLGRVIEKSHCPTPAALRKLFPTLDNFKYLDKHYVIDIANNNLRVVALIFFESQKF
YVRHVFTQKEYDRFTEKHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15515.05 Da        Isoelectric Point: 5.5699

>AT293995 WP_129741611.1 NZ_LT991957:2143536-2143955 [Enterobacter cloacae complex sp.]
MMIVADALKATHDLVAAVPLLGEHPNEKDYQDALELVEYLLMHEPGSPLLDIVCARISRYEANRPEIVALRQEMESVPVG
IAVLRTLMDQHKLTISDFQDEIGSKSMVSRVLNGQRQLTLNHIKKLAARFGVSPALFIE

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References