Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 900197..900854 Replicon chromosome
Accession NZ_LT991957
Organism Enterobacter cloacae complex sp. isolate C45

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DBR02_RS04605 Protein ID WP_107533572.1
Coordinates 900197..900496 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DBR02_RS04610 Protein ID WP_107533573.1
Coordinates 900507..900854 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBR02_RS04595 896508..898700 + 2193 WP_063451807.1 type I secretion system permease/ATPase -
DBR02_RS04600 898720..899880 + 1161 WP_102751329.1 HlyD family efflux transporter periplasmic adaptor subunit -
DBR02_RS04605 900197..900496 + 300 WP_107533572.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DBR02_RS04610 900507..900854 + 348 WP_107533573.1 HigA family addiction module antidote protein Antitoxin
DBR02_RS04615 900905..902086 - 1182 WP_107533574.1 PLP-dependent aminotransferase family protein -
DBR02_RS04620 902107..902994 - 888 WP_107533575.1 LysR family transcriptional regulator -
DBR02_RS04625 903092..903694 + 603 WP_107533576.1 short chain dehydrogenase -
DBR02_RS04630 903691..904422 - 732 WP_107533577.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11524.12 Da        Isoelectric Point: 10.0104

>T293991 WP_107533572.1 NZ_LT991957:900197-900496 [Enterobacter cloacae complex sp.]
MINHFRDQWLKDFFLYGKSSNVIPSSLESALARKLDMINAATSHRDLRSPPGNMYESLNPPLAGYSAIRVNRQYRLVFRW
SEGKADDLYLSPHKYTPYK

Download         Length: 300 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13146.07 Da        Isoelectric Point: 7.0141

>AT293991 WP_107533573.1 NZ_LT991957:900507-900854 [Enterobacter cloacae complex sp.]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAFRLAKAFDTTIEFWLNLQLNVD
VWEAQTNSRTQEELSRIKTVAEIMAKRKSGQPDVA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References