Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3179500..3180084 Replicon chromosome
Accession NZ_LT985188
Organism Micropruina glycogenica isolate

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag MPLG2_RS14940 Protein ID WP_105186822.1
Coordinates 3179803..3180084 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MPLG2_RS14935 Protein ID WP_105186821.1
Coordinates 3179500..3179793 (-) Length 98 a.a.

Genomic Context

MPLG2_RS14950MPLG2_RS14960MPLG2_RS14970MPLG2_RS14920MPLG2_RS14925MPLG2_RS14930MPLG2_RS14935MPLG2_RS14940MPLG2_RS14945MPLG2_RS14955MPLG2_RS14965MPLG2_RS14975
Location: 3181365..3181799 (435 bp)
Type: Others
Protein ID: WP_197709966.1
Location: 3182494..3182832 (339 bp)
Type: Others
Protein ID: WP_105186826.1
Location: 3183355..3183624 (270 bp)
Type: Others
Protein ID: WP_197709968.1
Location: 3175793..3176755 (963 bp)
Type: Others
Protein ID: WP_105186819.1
Location: 3176755..3176979 (225 bp)
Type: Others
Protein ID: WP_105186820.1
Location: 3177165..3179426 (2262 bp)
Type: Others
Protein ID: WP_197709965.1
Location: 3179500..3179793 (294 bp)
Type: Antitoxin
Protein ID: WP_105186821.1
Location: 3179803..3180084 (282 bp)
Type: Toxin
Protein ID: WP_105186822.1
Location: 3180081..3181232 (1152 bp)
Type: Others
Protein ID: WP_105186823.1
Location: 3181927..3182412 (486 bp)
Type: Others
Protein ID: WP_105186825.1
Location: 3182837..3183262 (426 bp)
Type: Others
Protein ID: WP_197709967.1
Location: 3183654..3184829 (1176 bp)
Type: Others
Protein ID: WP_105186828.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MPLG2_RS149203175793..3176755-963WP_105186819.1hypothetical protein-
MPLG2_RS149253176755..3176979-225WP_105186820.1hypothetical protein-
MPLG2_RS149303177165..3179426-2262WP_197709965.1formylglycine-generating enzyme family protein-
MPLG2_RS149353179500..3179793-294WP_105186821.1HigA family addiction module antidote proteinAntitoxin
MPLG2_RS149403179803..3180084-282WP_105186822.1type II toxin-antitoxin system RelE/ParE family toxinToxin
MPLG2_RS149453180081..3181232-1152WP_105186823.1alcohol dehydrogenase catalytic domain-containing protein-
MPLG2_RS149503181365..3181799+435WP_197709966.1excisionase family DNA-binding protein-
MPLG2_RS149553181927..3182412-486WP_105186825.1MarR family transcriptional regulator-
MPLG2_RS149603182494..3182832+339WP_105186826.1hypothetical protein-
MPLG2_RS149653182837..3183262-426WP_197709967.1hypothetical protein-
MPLG2_RS149703183355..3183624+270WP_197709968.1class I SAM-dependent methyltransferase-
MPLG2_RS149753183654..3184829-1176WP_105186828.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10910.40 Da        Isoelectric Point: 8.0513

>T293963 WP_105186822.1 NZ_LT985188:c3180084-3179803 [Micropruina glycogenica]
VIRSFRDSATERLWSRQRVKTIDPRIERAALRKLVMLDAAETLDDLRVPPGNRLEELRGDRAGQHSIRINQQWRICFTWT
DAGPIDVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11120.79 Da        Isoelectric Point: 6.2259

>AT293963 WP_105186821.1 NZ_LT985188:c3179793-3179500 [Micropruina glycogenica]
MTTTTPIHPGEILMEEFLEPLAVSQNRLAVAIGVPPRRINEIVHGKRRITADTALRLARYFGTTDRFWLNLQIRYDLEVE
KDHLGNSLDRIEPLEAV

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References