Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3179500..3180084 Replicon chromosome
Accession NZ_LT985188
Organism Micropruina glycogenica isolate

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag MPLG2_RS14940 Protein ID WP_105186822.1
Coordinates 3179803..3180084 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MPLG2_RS14935 Protein ID WP_105186821.1
Coordinates 3179500..3179793 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPLG2_RS14920 3175793..3176755 - 963 WP_105186819.1 hypothetical protein -
MPLG2_RS14925 3176755..3176979 - 225 WP_105186820.1 hypothetical protein -
MPLG2_RS14930 3177165..3179426 - 2262 WP_197709965.1 formylglycine-generating enzyme family protein -
MPLG2_RS14935 3179500..3179793 - 294 WP_105186821.1 HigA family addiction module antidote protein Antitoxin
MPLG2_RS14940 3179803..3180084 - 282 WP_105186822.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MPLG2_RS14945 3180081..3181232 - 1152 WP_105186823.1 alcohol dehydrogenase catalytic domain-containing protein -
MPLG2_RS14950 3181365..3181799 + 435 WP_197709966.1 excisionase family DNA-binding protein -
MPLG2_RS14955 3181927..3182412 - 486 WP_105186825.1 MarR family transcriptional regulator -
MPLG2_RS14960 3182494..3182832 + 339 WP_105186826.1 hypothetical protein -
MPLG2_RS14965 3182837..3183262 - 426 WP_197709967.1 hypothetical protein -
MPLG2_RS14970 3183355..3183624 + 270 WP_197709968.1 class I SAM-dependent methyltransferase -
MPLG2_RS14975 3183654..3184829 - 1176 WP_105186828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10910.40 Da        Isoelectric Point: 8.0513

>T293963 WP_105186822.1 NZ_LT985188:c3180084-3179803 [Micropruina glycogenica]
VIRSFRDSATERLWSRQRVKTIDPRIERAALRKLVMLDAAETLDDLRVPPGNRLEELRGDRAGQHSIRINQQWRICFTWT
DAGPIDVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11120.79 Da        Isoelectric Point: 6.2259

>AT293963 WP_105186821.1 NZ_LT985188:c3179793-3179500 [Micropruina glycogenica]
MTTTTPIHPGEILMEEFLEPLAVSQNRLAVAIGVPPRRINEIVHGKRRITADTALRLARYFGTTDRFWLNLQIRYDLEVE
KDHLGNSLDRIEPLEAV

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References