Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5974885..5975480 Replicon chromosome
Accession NZ_LT969520
Organism Pseudomonas aeruginosa isolate RW109

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag RW109_RS32230 Protein ID WP_003117425.1
Coordinates 5975202..5975480 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RW109_RS32225 Protein ID WP_003099268.1
Coordinates 5974885..5975190 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RW109_RS32190 5970024..5970872 + 849 WP_003162406.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
RW109_RS32200 5971039..5971980 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
RW109_RS32205 5972097..5972711 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
RW109_RS32210 5972753..5973337 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
RW109_RS32215 5973378..5974478 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
RW109_RS32225 5974885..5975190 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
RW109_RS32230 5975202..5975480 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RW109_RS32240 5975805..5978033 + 2229 WP_003113525.1 TonB-dependent receptor -
RW109_RS32245 5978103..5978750 - 648 WP_003095021.1 carbonate dehydratase -
RW109_RS32250 5978812..5980050 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T293951 WP_003117425.1 NZ_LT969520:c5975480-5975202 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT293951 WP_003099268.1 NZ_LT969520:c5975190-5974885 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References