Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 180170..180763 Replicon chromosome
Accession NZ_LT963408
Organism Pseudomonas syringae group genomosp. 3 isolate CFBP6411

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag C6H37_RS00945 Protein ID WP_005739894.1
Coordinates 180170..180448 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID Q88B19
Locus tag C6H37_RS00950 Protein ID WP_005739893.1
Coordinates 180458..180763 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6H37_RS00925 175322..176155 - 834 WP_005739898.1 transporter substrate-binding domain-containing protein -
C6H37_RS00930 176183..177055 - 873 WP_005613618.1 phytanoyl-CoA dioxygenase family protein -
C6H37_RS00935 177080..178600 - 1521 WP_005739897.1 amino acid ABC transporter permease/ATP-binding protein -
C6H37_RS00940 179085..179999 + 915 WP_019332092.1 LysR family transcriptional regulator -
C6H37_RS00945 180170..180448 + 279 WP_005739894.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6H37_RS00950 180458..180763 + 306 WP_005739893.1 HigA family addiction module antidote protein Antitoxin
C6H37_RS00955 180797..181078 - 282 WP_005739892.1 accessory factor UbiK family protein -
C6H37_RS00965 181498..181836 + 339 WP_002555808.1 P-II family nitrogen regulator -
C6H37_RS00970 181871..183208 + 1338 WP_005739890.1 ammonium transporter -
C6H37_RS00980 183451..183876 + 426 WP_005739889.1 secondary thiamine-phosphate synthase enzyme YjbQ -
C6H37_RS00985 183975..184307 + 333 WP_003377934.1 hypothetical protein -
C6H37_RS00990 184382..185074 - 693 WP_005739888.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10411.07 Da        Isoelectric Point: 9.1490

>T293923 WP_005739894.1 NZ_LT963408:180170-180448 [Pseudomonas syringae group genomosp. 3]
MIVSFKCVHTRYLFLQGKTRLLPSIKSVAERKLAMLDAATSILDLRSPPGNRLEALDGSRSGQYSVRINAQFRICFVWSI
NGPEDVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11158.01 Da        Isoelectric Point: 7.7509

>AT293923 WP_005739893.1 NZ_LT963408:180458-180763 [Pseudomonas syringae group genomosp. 3]
MNKNGMRPVHPGEVLKEEYLEPMGLTAAALARALKVSTPTVNDIVLQRRGVSADVALRLAVCLETSPEFWLNLQLAYDLR
KAETEKGAQIREQVKCLAHCA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0K8LYY6

References