Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 181751..182344 Replicon chromosome
Accession NZ_LT963402
Organism Pseudomonas syringae pv. avii isolate CFBP3846

Toxin (Protein)


Gene name graT Uniprot ID Q88B20
Locus tag C6H38_RS00905 Protein ID WP_011103035.1
Coordinates 181751..182029 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID Q88B19
Locus tag C6H38_RS00910 Protein ID WP_005739893.1
Coordinates 182039..182344 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6H38_RS00885 177012..178250 - 1239 WP_060414024.1 diaminopimelate decarboxylase -
C6H38_RS00890 178252..179127 - 876 WP_060414023.1 DMT family transporter -
C6H38_RS00895 179127..180410 - 1284 WP_060414022.1 lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein -
C6H38_RS00900 180565..181500 + 936 WP_005739904.1 LysR family transcriptional regulator -
C6H38_RS00905 181751..182029 + 279 WP_011103035.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6H38_RS00910 182039..182344 + 306 WP_005739893.1 HigA family addiction module antidote protein Antitoxin
C6H38_RS00915 182378..182659 - 282 WP_005768515.1 accessory factor UbiK family protein -
C6H38_RS00925 183079..183417 + 339 WP_002555808.1 P-II family nitrogen regulator -
C6H38_RS00930 183453..184790 + 1338 WP_005739890.1 ammonium transporter -
C6H38_RS00940 185033..185460 + 428 Protein_175 YjbQ family protein -
C6H38_RS00945 185559..185891 + 333 WP_007246533.1 hypothetical protein -
C6H38_RS00950 185966..186658 - 693 WP_007246534.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10453.11 Da        Isoelectric Point: 9.1490

>T293904 WP_011103035.1 NZ_LT963402:181751-182029 [Pseudomonas syringae pv. avii]
MIVSFKCVHTRYLFLQGKTRLWPSIKSVAERKLAMLDAATSILDLRSPPGNRLEALDGSRSGQYSVRINAPFRICFVWSI
NGPEDVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11158.01 Da        Isoelectric Point: 7.7509

>AT293904 WP_005739893.1 NZ_LT963402:182039-182344 [Pseudomonas syringae pv. avii]
MNKNGMRPVHPGEVLKEEYLEPMGLTAAALARALKVSTPTVNDIVLQRRGVSADVALRLAVCLETSPEFWLNLQLAYDLR
KAETEKGAQIREQVKCLAHCA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q88B20

Antitoxin

Source ID Structure
AlphaFold DB A0A0K8LYY6

References