Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
| Location | 3296871..3297478 | Replicon | chromosome |
| Accession | NC_021150 | ||
| Organism | Azotobacter vinelandii CA6 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | M9YKU8 |
| Locus tag | AVCA6_RS14580 | Protein ID | WP_012701744.1 |
| Coordinates | 3297164..3297478 (-) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | AVCA6_RS14575 | Protein ID | WP_012701743.1 |
| Coordinates | 3296871..3297158 (-) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AVCA6_RS14525 | 3291898..3292995 | - | 1098 | WP_012701731.1 | glycine cleavage system aminomethyltransferase GcvT | - |
| AVCA6_RS14530 | 3293009..3293386 | - | 378 | WP_012701732.1 | type II toxin-antitoxin system VapC family toxin | - |
| AVCA6_RS14535 | 3293383..3293628 | - | 246 | WP_012701733.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| AVCA6_RS14540 | 3293923..3294318 | + | 396 | WP_012701734.1 | hypothetical protein | - |
| AVCA6_RS14545 | 3294480..3294683 | - | 204 | WP_012701735.1 | hypothetical protein | - |
| AVCA6_RS24890 | 3294833..3295030 | + | 198 | WP_012701736.1 | HNH endonuclease | - |
| AVCA6_RS14550 | 3295236..3295418 | - | 183 | Protein_2913 | type II toxin-antitoxin system HigB family toxin | - |
| AVCA6_RS14555 | 3295631..3296008 | - | 378 | WP_012701739.1 | transcriptional regulator | - |
| AVCA6_RS25570 | 3296014..3296121 | - | 108 | Protein_2915 | type II toxin-antitoxin system HigB family toxin | - |
| AVCA6_RS14565 | 3296115..3296420 | - | 306 | WP_012701741.1 | BrnA antitoxin family protein | - |
| AVCA6_RS14570 | 3296404..3296673 | - | 270 | WP_012701742.1 | BrnT family toxin | - |
| AVCA6_RS14575 | 3296871..3297158 | - | 288 | WP_012701743.1 | helix-turn-helix domain-containing protein | Antitoxin |
| AVCA6_RS14580 | 3297164..3297478 | - | 315 | WP_012701744.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AVCA6_RS24895 | 3298117..3299184 | + | 1068 | WP_012701745.1 | hypothetical protein | - |
| AVCA6_RS14585 | 3299298..3299741 | - | 444 | WP_041807276.1 | hypothetical protein | - |
| AVCA6_RS26250 | 3299738..3300034 | - | 297 | WP_175555999.1 | hypothetical protein | - |
| AVCA6_RS24900 | 3300146..3300850 | - | 705 | WP_012701749.1 | hypothetical protein | - |
| AVCA6_RS14590 | 3300959..3302320 | + | 1362 | WP_012701750.1 | IS701-like element ISAzvi8 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11885.67 Da Isoelectric Point: 8.8937
>T29387 WP_012701744.1 NC_021150:c3297478-3297164 [Azotobacter vinelandii CA6]
MIFIETPIFTRCLRELLDDDSYAAFQKTLAERLDAGDVIEGTGGIRKVRVASKGHGKRGGSRVIYYHFVSESQIALLLIY
PKNEKDDLTADERKALKRIIETWR
MIFIETPIFTRCLRELLDDDSYAAFQKTLAERLDAGDVIEGTGGIRKVRVASKGHGKRGGSRVIYYHFVSESQIALLLIY
PKNEKDDLTADERKALKRIIETWR
Download Length: 315 bp
>T29387 NC_021150:c3297478-3297164 [Azotobacter vinelandii CA6]
ATGATATTCATCGAAACCCCCATATTCACCAGATGCCTGCGCGAGTTGCTGGATGACGACAGCTATGCAGCCTTCCAGAA
GACGCTGGCCGAGCGCCTCGATGCCGGCGATGTCATCGAGGGCACTGGAGGCATTCGGAAGGTGCGTGTCGCCTCGAAGG
GGCATGGAAAACGGGGTGGCTCCCGGGTTATCTACTATCACTTCGTCTCGGAATCGCAGATCGCCCTGCTGCTGATCTAT
CCGAAGAACGAGAAGGATGACCTGACTGCCGACGAGCGCAAAGCGCTCAAACGCATCATCGAGACGTGGAGGTAA
ATGATATTCATCGAAACCCCCATATTCACCAGATGCCTGCGCGAGTTGCTGGATGACGACAGCTATGCAGCCTTCCAGAA
GACGCTGGCCGAGCGCCTCGATGCCGGCGATGTCATCGAGGGCACTGGAGGCATTCGGAAGGTGCGTGTCGCCTCGAAGG
GGCATGGAAAACGGGGTGGCTCCCGGGTTATCTACTATCACTTCGTCTCGGAATCGCAGATCGCCCTGCTGCTGATCTAT
CCGAAGAACGAGAAGGATGACCTGACTGCCGACGAGCGCAAAGCGCTCAAACGCATCATCGAGACGTGGAGGTAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10703.28 Da Isoelectric Point: 8.8270
>AT29387 WP_012701743.1 NC_021150:c3297158-3296871 [Azotobacter vinelandii CA6]
MSKFFDDLMESVVQMDEIVRGERQPSREFTVDALQVKQIRKATGLSQAKFAAMIDVQVGTLRNWEQGRREPTGPAKALLR
AIHNDPEHVIRALAG
MSKFFDDLMESVVQMDEIVRGERQPSREFTVDALQVKQIRKATGLSQAKFAAMIDVQVGTLRNWEQGRREPTGPAKALLR
AIHNDPEHVIRALAG
Download Length: 288 bp
>AT29387 NC_021150:c3297158-3296871 [Azotobacter vinelandii CA6]
ATGAGTAAGTTTTTCGACGACCTCATGGAAAGCGTCGTGCAAATGGACGAAATCGTTCGCGGCGAACGCCAGCCGTCCCG
CGAGTTCACCGTGGATGCCTTGCAGGTGAAGCAGATCCGCAAGGCCACCGGTCTTTCGCAGGCCAAGTTTGCCGCGATGA
TCGATGTGCAGGTGGGCACTCTGCGCAACTGGGAGCAAGGCCGCCGCGAGCCGACCGGCCCGGCCAAGGCTCTGCTGCGC
GCCATCCACAATGACCCGGAGCACGTCATTCGAGCGCTGGCGGGCTAA
ATGAGTAAGTTTTTCGACGACCTCATGGAAAGCGTCGTGCAAATGGACGAAATCGTTCGCGGCGAACGCCAGCCGTCCCG
CGAGTTCACCGTGGATGCCTTGCAGGTGAAGCAGATCCGCAAGGCCACCGGTCTTTCGCAGGCCAAGTTTGCCGCGATGA
TCGATGTGCAGGTGGGCACTCTGCGCAACTGGGAGCAAGGCCGCCGCGAGCCGACCGGCCCGGCCAAGGCTCTGCTGCGC
GCCATCCACAATGACCCGGAGCACGTCATTCGAGCGCTGGCGGGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|