Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 529899..530529 Replicon chromosome
Accession NZ_LT962688
Organism Methylorubrum extorquens strain TK 0001

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag TK0001_RS02700 Protein ID WP_056505670.1
Coordinates 530203..530529 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag TK0001_RS02695 Protein ID WP_015952796.1
Coordinates 529899..530192 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TK0001_RS02670 525957..526436 - 480 WP_056505677.1 YaiI/YqxD family protein -
TK0001_RS02675 526433..527593 - 1161 WP_056505674.1 lipid-A-disaccharide synthase -
TK0001_RS02680 527590..528440 - 851 Protein_524 UDP-2,3-diacylglucosamine diphosphatase LpxI -
TK0001_RS02685 528474..529259 - 786 Protein_525 acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase -
TK0001_RS02690 529265..529726 - 462 WP_003603892.1 3-hydroxyacyl-ACP dehydratase FabZ -
TK0001_RS02695 529899..530192 - 294 WP_015952796.1 transcriptional regulator Antitoxin
TK0001_RS02700 530203..530529 - 327 WP_056505670.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TK0001_RS02705 530624..531850 - 1227 WP_101475399.1 molybdopterin molybdotransferase MoeA -
TK0001_RS02710 531847..532332 - 486 WP_012255726.1 cyclic pyranopterin monophosphate synthase MoaC -
TK0001_RS02715 532329..533186 - 858 WP_056505666.1 indole-3-glycerol phosphate synthase TrpC -
TK0001_RS02720 533220..534233 - 1014 WP_056505664.1 anthranilate phosphoribosyltransferase -
TK0001_RS02725 534322..534924 - 603 WP_056505660.1 aminodeoxychorismate/anthranilate synthase component II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(48-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-85)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11548.40 Da        Isoelectric Point: 9.0031

>T293863 WP_056505670.1 NZ_LT962688:c530529-530203 [Methylorubrum extorquens]
MADALHTVIETEIYLRSAERLMIEAERAAVVDILAADPFAGDVIPGTGGLRKVRVPLNGRGKRGGARVITCFVSARGVYL
LLAYAKNEQANPTPAQAQGLARLVDTLF

Download         Length: 327 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10675.10 Da        Isoelectric Point: 9.1578

>AT293863 WP_015952796.1 NZ_LT962688:c530192-529899 [Methylorubrum extorquens]
MDEATFQELTRSLEQAAAHARGETVAGLQVHVPHDIDVAAVRRASALSQDAFARRIGVAVGTLRNWEQRRRRPEGPARVL
LALLEKNPRLVEETLGG

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References