Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3488847..3489476 Replicon chromosome
Accession NZ_LT934425
Organism Candidatus Kuenenia stuttgartiensis isolate kuenenia_mbr1_ru-nijmegen

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag KSMBR1_RS16315 Protein ID WP_099326265.1
Coordinates 3488847..3489140 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag KSMBR1_RS16320 Protein ID WP_099326266.1
Coordinates 3489159..3489476 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSMBR1_RS16290 3484258..3485772 + 1515 WP_099326261.1 IMP dehydrogenase -
KSMBR1_RS16295 3486163..3487281 + 1119 WP_099326262.1 acyltransferase -
KSMBR1_RS16300 3487355..3487543 + 189 WP_099326263.1 hypothetical protein -
KSMBR1_RS16305 3487687..3487815 + 129 WP_197705231.1 type II toxin-antitoxin system RelE/ParE family toxin -
KSMBR1_RS22110 3488113..3488229 + 117 WP_197705232.1 hypothetical protein -
KSMBR1_RS22115 3488411..3488554 + 144 WP_197705233.1 hypothetical protein -
KSMBR1_RS16315 3488847..3489140 + 294 WP_099326265.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KSMBR1_RS16320 3489159..3489476 + 318 WP_099326266.1 HigA family addiction module antidote protein Antitoxin
KSMBR1_RS16325 3489643..3490023 + 381 WP_099326267.1 hypothetical protein -
KSMBR1_RS16330 3490227..3490784 + 558 WP_157820667.1 GNAT family N-acetyltransferase -
KSMBR1_RS16335 3490968..3492491 + 1524 WP_099326269.1 IS1380-like element ISCku9 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3490968..3492491 1523


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-72)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11222.65 Da        Isoelectric Point: 7.2446

>T293842 WP_099326265.1 NZ_LT934425:3488847-3489140 [Candidatus Kuenenia stuttgartiensis]
VIQSFHDKGTEDIFDRKNTREARKTCPQQIWRAAQRKLDQLNGVVSLGSLKIPPGNMLEVLKDDRKGQHSIRINDQFRVC
FVWADDGVDNVEITDYH

Download         Length: 294 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12152.29 Da        Isoelectric Point: 10.0019

>AT293842 WP_099326266.1 NZ_LT934425:3489159-3489476 [Candidatus Kuenenia stuttgartiensis]
MVRIPKNGPPTHPGEMLLEEFLKPLHMTQRELAEKLGVSYPRVNELIHGKRGMTPDTALRLEKLFGMDAQFWLNLQLAWD
LYHVTHSSTAKEIQKIKRLPAFIHV

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References