Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1210361..1210894 Replicon chromosome
Accession NZ_LT934425
Organism Candidatus Kuenenia stuttgartiensis isolate kuenenia_mbr1_ru-nijmegen

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KSMBR1_RS05560 Protein ID WP_099324421.1
Coordinates 1210361..1210567 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KSMBR1_RS05565 Protein ID WP_099324422.1
Coordinates 1210580..1210894 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSMBR1_RS05535 1205862..1206071 - 210 WP_099324419.1 hypothetical protein -
KSMBR1_RS05545 1206482..1207585 - 1104 WP_099323638.1 IS4-like element ISCku3 family transposase -
KSMBR1_RS05550 1207654..1208007 - 354 WP_197705356.1 MBL fold metallo-hydrolase -
KSMBR1_RS21510 1208192..1208368 - 177 WP_164994612.1 hypothetical protein -
KSMBR1_RS05555 1208746..1210302 + 1557 WP_099323647.1 hypothetical protein -
KSMBR1_RS05560 1210361..1210567 + 207 WP_099324421.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KSMBR1_RS05565 1210580..1210894 + 315 WP_099324422.1 HigA family addiction module antidote protein Antitoxin
KSMBR1_RS05570 1211261..1212037 - 777 WP_099324423.1 hypothetical protein -
KSMBR1_RS05575 1212169..1212354 - 186 WP_099324424.1 hypothetical protein -
KSMBR1_RS05580 1212430..1213284 - 855 WP_099324425.1 hypothetical protein -
KSMBR1_RS05585 1213646..1214242 - 597 WP_099324426.1 hypothetical protein -
KSMBR1_RS05590 1214467..1214625 - 159 WP_099324427.1 DUF3309 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1215118..1216221 1103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-68)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 8155.29 Da        Isoelectric Point: 7.2776

>T293839 WP_099324421.1 NZ_LT934425:1210361-1210567 [Candidatus Kuenenia stuttgartiensis]
MQMRAFAKLNAIDAAIHLKDLHLPPSNRFEALKGERKEQYSIRINDRWRICFEWRNGNAEEVEIVDYH

Download         Length: 207 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12280.28 Da        Isoelectric Point: 10.4296

>AT293839 WP_099324422.1 NZ_LT934425:1210580-1210894 [Candidatus Kuenenia stuttgartiensis]
MAKRRITPVHPGVYLKELLDELKISQYRLSQDLGVPAMRINHVVHSKRPVTAELALRLGRYFGQSPRYWMNLQSRYDMDI
AEDALFEQVTREVRPFNGRFIIHK

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References