Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 258502..259068 Replicon chromosome
Accession NZ_LT907988
Organism Orrella dioscoreae isolate Orrdi1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ODI_RS01250 Protein ID WP_067753524.1
Coordinates 258790..259068 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1C3K1T8
Locus tag ODI_RS01245 Protein ID WP_067753526.1
Coordinates 258502..258780 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ODI_RS01230 254964..256406 - 1443 WP_067753533.1 GTPase/DUF3482 domain-containing protein -
ODI_RS01235 256399..257796 - 1398 WP_067753530.1 DUF2868 domain-containing protein -
ODI_RS01240 257973..258347 + 375 WP_067753528.1 oxalurate catabolism protein HpxZ -
ODI_RS01245 258502..258780 - 279 WP_067753526.1 HigA family addiction module antidote protein Antitoxin
ODI_RS01250 258790..259068 - 279 WP_067753524.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ODI_RS01260 259394..259867 - 474 WP_067753519.1 ClpXP protease specificity-enhancing factor -
ODI_RS01265 259870..260481 - 612 WP_067753517.1 glutathione S-transferase N-terminal domain-containing protein -
ODI_RS01270 260587..261438 - 852 WP_098020810.1 cytochrome c1 -
ODI_RS01275 261461..262846 - 1386 WP_067753514.1 cytochrome bc complex cytochrome b subunit -
ODI_RS01280 262918..263559 - 642 WP_067753511.1 ubiquinol-cytochrome c reductase iron-sulfur subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-67)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10603.10 Da        Isoelectric Point: 10.0902

>T293812 WP_067753524.1 NZ_LT907988:c259068-258790 [Orrella dioscoreae]
MILSFQHRGLRRFFDTGSVAGIQPHHADKLRELLTALNAASAPADLARPSWRYHMLTGKQKGFASLTVNGNWRLIFRWHG
QDVELLDYLDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10011.42 Da        Isoelectric Point: 6.9870

>AT293812 WP_067753526.1 NZ_LT907988:c258780-258502 [Orrella dioscoreae]
MHMHNPAHPGEILAGWLADLGTSITAFAAHIGLSRVLVSRILHAKAGITADTDLRLSDALGTTPGYWLRIQGQYDLWQAS
QNDRPVIERLAA

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C3K1T8

References