Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3385400..3386066 Replicon chromosome
Accession NZ_LT906483
Organism Mycolicibacterium thermoresistibile strain NCTC10409

Toxin (Protein)


Gene name higB Uniprot ID G7CGA7
Locus tag CKW28_RS15865 Protein ID WP_003925523.1
Coordinates 3385400..3385738 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CKW28_RS15870 Protein ID WP_040546732.1
Coordinates 3385740..3386066 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW28_RS15845 3380546..3382198 - 1653 WP_003925520.1 arginine--tRNA ligase -
CKW28_RS15850 3382410..3382859 + 450 WP_003925521.1 hypothetical protein -
CKW28_RS15860 3383556..3385130 + 1575 WP_003925522.1 hypothetical protein -
CKW28_RS15865 3385400..3385738 + 339 WP_003925523.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CKW28_RS15870 3385740..3386066 + 327 WP_040546732.1 XRE family transcriptional regulator Antitoxin
CKW28_RS23935 3386313..3386491 - 179 Protein_3137 YegP family protein -
CKW28_RS15880 3386701..3387909 + 1209 Protein_3138 IS21 family transposase -
CKW28_RS15890 3388818..3389246 - 429 WP_061252274.1 OB-fold domain-containing protein -
CKW28_RS15895 3389248..3390438 - 1191 WP_003890696.1 thiolase family protein -
CKW28_RS15900 3390519..3391037 - 519 WP_003890697.1 MaoC family dehydratase N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-71)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13074.88 Da        Isoelectric Point: 5.2420

>T293784 WP_003925523.1 NZ_LT906483:3385400-3385738 [Mycolicibacterium thermoresistibile]
MWEVILVEEVEQWFFSLDPDVIDVVTGAIDRLEESGPALGRPTADRVKGSKYHHMKELRPAGTSIRILYIFDPTRRAVLL
VAGDKAGQWKKWYQDNIPVAEQRYERWFERGE

Download         Length: 339 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11949.75 Da        Isoelectric Point: 10.4321

>AT293784 WP_040546732.1 NZ_LT906483:3385740-3386066 [Mycolicibacterium thermoresistibile]
MARSWRDVRAEAVASGRVDPARADAARRRMKVMEHAHTLAEVRKTLGMLRQEDIAQRMGVSQARVSKLERGDLAHTELGT
LLSYIQAMGGELKIEARIGDNSIDLIPA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7CGA7

Antitoxin

Source ID Structure

References