Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4199244..4199896 Replicon chromosome
Accession NZ_LT906479
Organism Serratia ficaria strain NCTC12148

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CKW09_RS19780 Protein ID WP_095099029.1
Coordinates 4199244..4199588 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CKW09_RS19785 Protein ID WP_095099032.1
Coordinates 4199594..4199896 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW09_RS19765 4194447..4196714 - 2268 WP_095100278.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
CKW09_RS19770 4196936..4197955 + 1020 WP_061796819.1 HTH-type transcriptional regulator GalR -
CKW09_RS19775 4198094..4199104 + 1011 WP_095099026.1 LacI family DNA-binding transcriptional regulator -
CKW09_RS19780 4199244..4199588 + 345 WP_095099029.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CKW09_RS19785 4199594..4199896 + 303 WP_095099032.1 helix-turn-helix transcriptional regulator Antitoxin
CKW09_RS19790 4199925..4201187 - 1263 WP_061796827.1 diaminopimelate decarboxylase -
CKW09_RS19795 4201321..4202244 + 924 WP_061796828.1 LysR family transcriptional regulator -
CKW09_RS19800 4202234..4203388 - 1155 WP_061796830.1 MFS transporter -
CKW09_RS19805 4203707..4204615 - 909 WP_095099035.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(19-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13252.31 Da        Isoelectric Point: 10.1599

>T293777 WP_095099029.1 NZ_LT906479:4199244-4199588 [Serratia ficaria]
MWQVATVEIFDAWFLSLSGDQQKSILAGIFKLQEFGPQLARPYADTLHFPGSIHRMKELRIQHRGHPFRFFFAFDPQRQA
VLLCGGDKTGDKRFCQRLLPIAAREFSHYLATQR

Download         Length: 345 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11161.07 Da        Isoelectric Point: 10.6886

>AT293777 WP_095099032.1 NZ_LT906479:4199594-4199896 [Serratia ficaria]
MAKPLSHRIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVRLPNGQHRRMTL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References