Detailed information of TA system TA293765

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA(toxin)
• Location: 2688737..2689974
• Replicon: chromosome
• Accession: NZ_LT906476
• Organism: Legionella pneumophila strain NCTC11286

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: CKV96_RS12270
• Protein ID: WP_027224428.1
• Coordinates: 2689042..2689974 (+)
• Length: 311 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: -
• Locus tag: CKV96_RS12265
• Protein ID: WP_027224429.1
• Coordinates: 2688737..2689045 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CKV96_RS12240	2684423..2684620	-	198	WP_014842401.1	hypothetical protein	-
CKV96_RS12245	2684640..2685866	-	1227	WP_027224432.1	MFS transporter	-
CKV96_RS12250	2686501..2686974	+	474	WP_027224431.1	hypothetical protein	-
CKV96_RS12255	2687153..2688070	+	918	WP_027224430.1	LysR family transcriptional regulator	-
CKV96_RS12260	2688513..2688740	+	228	WP_013101792.1	helix-turn-helix transcriptional regulator	-
CKV96_RS12265	2688737..2689045	+	309	WP_027224429.1	HipA N-terminal domain-containing protein	Antitoxin
CKV96_RS12270	2689042..2689974	+	933	WP_027224428.1	HipA domain-containing protein	Toxin
CKV96_RS12275	2690103..2692670	+	2568	WP_027224427.1	magnesium-translocating P-type ATPase	-
CKV96_RS12280	2692705..2693649	+	945	WP_027224426.1	flippase-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (53-279)

Antitoxin

• HipA, N-terminal subdomain 1 (5-98)

Sequences

Toxin

Protein

• Length: 311 a.a.
• Molecular weight: 35780.41 Da
• Isoelectric Point: 9.5904

>T293765 WP_027224428.1 NZ_LT906476:2689042-2689974 [Legionella pneumophila]
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGSFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAIIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITRDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
KKNNLTKSDFLNYFAVEKLGLNQNVINGIAQEFHQAIPEWRELISFSFLSQPMQEKYLQLLDQRCKRLNF

Nucleotide

• Length: 933 bp

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11586.38 Da
• Isoelectric Point: 4.5859

>AT293765 WP_027224429.1 NZ_LT906476:2688737-2689045 [Legionella pneumophila]
MRKAYVSVNGIKAGILEELQSGKYQFSYFDDYHGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLIIVGQDVVGAVTIEEIR

Nucleotide

• Length: 309 bp