293764

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2653796..2655039 Replicon chromosome
Accession NZ_LT906476
Organism Legionella pneumophila strain NCTC11286

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag CKV96_RS12055 Protein ID WP_027224015.1
Coordinates 2654101..2655039 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A1E5JNB7
Locus tag CKV96_RS12050 Protein ID WP_027224016.1
Coordinates 2653796..2654104 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV96_RS12030 2649323..2650447 - 1125 WP_027224020.1 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -
CKV96_RS12035 2650823..2652574 - 1752 WP_027224019.1 DUF927 domain-containing protein -
CKV96_RS12040 2652658..2652933 - 276 WP_027224018.1 helix-turn-helix domain-containing protein -
CKV96_RS12045 2653572..2653799 + 228 WP_027224017.1 helix-turn-helix transcriptional regulator -
CKV96_RS12050 2653796..2654104 + 309 WP_027224016.1 HipA N-terminal domain-containing protein Antitoxin
CKV96_RS12055 2654101..2655039 + 939 WP_027224015.1 lpg2370 family Dot/Icm T4SS effector Toxin
CKV96_RS12060 2655036..2655227 - 192 WP_032829667.1 hypothetical protein -
CKV96_RS12065 2655329..2655754 - 426 WP_027224014.1 helix-turn-helix domain-containing protein -
CKV96_RS12070 2655757..2656044 - 288 WP_027224013.1 type II toxin-antitoxin system HigB family toxin -
CKV96_RS12075 2656108..2657337 - 1230 WP_027224012.1 integrase family protein -
CKV96_RS12080 2657582..2658568 - 987 WP_042236413.1 IS30 family transposase -
CKV96_RS12085 2658750..2659538 + 789 WP_014844522.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - lpg2370 2635516..2686180 50664


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36029.85 Da        Isoelectric Point: 9.1296

>T293764 WP_027224015.1 NZ_LT906476:2654101-2655039 [Legionella pneumophila]
MKHCPITYEKISVQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQPMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11626.49 Da        Isoelectric Point: 4.6017

>AT293764 WP_027224016.1 NZ_LT906476:2653796-2654104 [Legionella pneumophila]
MRKAYVSVNGIRAGILEELEGKKYQFTYLNDYQGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEELR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1E5JNB7

References