293757

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3586169..3587867 Replicon chromosome
Accession NZ_LT906474
Organism Escherichia coli strain NCTC122

Toxin (Protein)


Gene name mosT Uniprot ID A0A3Y1KBU9
Locus tag CKV98_RS18225 Protein ID WP_047085429.1
Coordinates 3586169..3587098 (-) Length 310 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag CKV98_RS18230 Protein ID WP_172808160.1
Coordinates 3587085..3587867 (-) Length 261 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV98_RS18195 3581597..3583105 + 1509 WP_032206693.1 group II intron reverse transcriptase/maturase -
CKV98_RS18200 3583195..3583668 + 474 Protein_3336 IS3 family transposase -
CKV98_RS18205 3583707..3583886 - 180 Protein_3337 hypothetical protein -
CKV98_RS18210 3584052..3584774 - 723 WP_081508859.1 SDR family oxidoreductase -
CKV98_RS18215 3584873..3585772 + 900 WP_000687182.1 LysR family transcriptional regulator -
CKV98_RS18225 3586169..3587098 - 930 WP_047085429.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CKV98_RS18230 3587085..3587867 - 783 WP_172808160.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
CKV98_RS18235 3588151..3589815 + 1665 Protein_3342 type I restriction endonuclease subunit R -
CKV98_RS18240 3589881..3591043 + 1163 WP_085947598.1 IS3-like element IS3 family transposase -
CKV98_RS18245 3591073..3591408 - 336 Protein_3344 type III restriction endonuclease subunit R -
CKV98_RS18250 3591464..3592161 + 698 Protein_3345 IS1 family transposase -
CKV98_RS18260 3592178..3592381 - 204 Protein_3346 DUF3987 domain-containing protein -
CKV98_RS23965 3592440..3592535 + 96 WP_211180486.1 putative translational regulatory protein ArgL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3578439..3605054 26615


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-261)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(3-90)


Sequences

Toxin        


Download         Length: 310 a.a.        Molecular weight: 34960.38 Da        Isoelectric Point: 7.3232

>T293757 WP_047085429.1 NZ_LT906474:c3587098-3586169 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNSK
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMSVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKRNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVSKLERVLEQYS

Download         Length: 930 bp

Antitoxin


Download         Length: 261 a.a.        Molecular weight: 29183.36 Da        Isoelectric Point: 8.5995

>AT293757 WP_172808160.1 NZ_LT906474:c3587867-3587085 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKSVRVAGLT
SLALQGHAHYTEPGRPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVTPFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGSGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Download         Length: 783 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y1KBU9

Antitoxin

Source ID Structure

References