Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
| Location | 3296883..3297490 | Replicon | chromosome |
| Accession | NC_021149 | ||
| Organism | Azotobacter vinelandii CA | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | M9YKU8 |
| Locus tag | AVCA_RS14575 | Protein ID | WP_012701744.1 |
| Coordinates | 3297176..3297490 (-) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | AVCA_RS14570 | Protein ID | WP_012701743.1 |
| Coordinates | 3296883..3297170 (-) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AVCA_RS14520 | 3291910..3293007 | - | 1098 | WP_012701731.1 | glycine cleavage system aminomethyltransferase GcvT | - |
| AVCA_RS14525 | 3293021..3293398 | - | 378 | WP_012701732.1 | type II toxin-antitoxin system VapC family toxin | - |
| AVCA_RS14530 | 3293395..3293640 | - | 246 | WP_012701733.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| AVCA_RS14535 | 3293935..3294330 | + | 396 | WP_012701734.1 | hypothetical protein | - |
| AVCA_RS14540 | 3294492..3294695 | - | 204 | WP_012701735.1 | hypothetical protein | - |
| AVCA_RS25085 | 3294845..3295042 | + | 198 | WP_012701736.1 | HNH endonuclease | - |
| AVCA_RS14545 | 3295248..3295430 | - | 183 | Protein_2912 | type II toxin-antitoxin system HigB family toxin | - |
| AVCA_RS14550 | 3295643..3296020 | - | 378 | WP_012701739.1 | transcriptional regulator | - |
| AVCA_RS25770 | 3296026..3296133 | - | 108 | Protein_2914 | type II toxin-antitoxin system HigB family toxin | - |
| AVCA_RS14560 | 3296127..3296432 | - | 306 | WP_012701741.1 | BrnA antitoxin family protein | - |
| AVCA_RS14565 | 3296416..3296685 | - | 270 | WP_012701742.1 | BrnT family toxin | - |
| AVCA_RS14570 | 3296883..3297170 | - | 288 | WP_012701743.1 | helix-turn-helix domain-containing protein | Antitoxin |
| AVCA_RS14575 | 3297176..3297490 | - | 315 | WP_012701744.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AVCA_RS25090 | 3298129..3299196 | + | 1068 | WP_012701745.1 | hypothetical protein | - |
| AVCA_RS14580 | 3299310..3299753 | - | 444 | WP_041807276.1 | hypothetical protein | - |
| AVCA_RS26460 | 3299750..3300046 | - | 297 | WP_175555999.1 | hypothetical protein | - |
| AVCA_RS25095 | 3300158..3300862 | - | 705 | WP_012701749.1 | hypothetical protein | - |
| AVCA_RS14585 | 3300971..3302332 | + | 1362 | WP_012701750.1 | IS701-like element ISAzvi8 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11885.67 Da Isoelectric Point: 8.8937
>T29375 WP_012701744.1 NC_021149:c3297490-3297176 [Azotobacter vinelandii CA]
MIFIETPIFTRCLRELLDDDSYAAFQKTLAERLDAGDVIEGTGGIRKVRVASKGHGKRGGSRVIYYHFVSESQIALLLIY
PKNEKDDLTADERKALKRIIETWR
MIFIETPIFTRCLRELLDDDSYAAFQKTLAERLDAGDVIEGTGGIRKVRVASKGHGKRGGSRVIYYHFVSESQIALLLIY
PKNEKDDLTADERKALKRIIETWR
Download Length: 315 bp
>T29375 NC_021149:c3297490-3297176 [Azotobacter vinelandii CA]
ATGATATTCATCGAAACCCCCATATTCACCAGATGCCTGCGCGAGTTGCTGGATGACGACAGCTATGCAGCCTTCCAGAA
GACGCTGGCCGAGCGCCTCGATGCCGGCGATGTCATCGAGGGCACTGGAGGCATTCGGAAGGTGCGTGTCGCCTCGAAGG
GGCATGGAAAACGGGGTGGCTCCCGGGTTATCTACTATCACTTCGTCTCGGAATCGCAGATCGCCCTGCTGCTGATCTAT
CCGAAGAACGAGAAGGATGACCTGACTGCCGACGAGCGCAAAGCGCTCAAACGCATCATCGAGACGTGGAGGTAA
ATGATATTCATCGAAACCCCCATATTCACCAGATGCCTGCGCGAGTTGCTGGATGACGACAGCTATGCAGCCTTCCAGAA
GACGCTGGCCGAGCGCCTCGATGCCGGCGATGTCATCGAGGGCACTGGAGGCATTCGGAAGGTGCGTGTCGCCTCGAAGG
GGCATGGAAAACGGGGTGGCTCCCGGGTTATCTACTATCACTTCGTCTCGGAATCGCAGATCGCCCTGCTGCTGATCTAT
CCGAAGAACGAGAAGGATGACCTGACTGCCGACGAGCGCAAAGCGCTCAAACGCATCATCGAGACGTGGAGGTAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10703.28 Da Isoelectric Point: 8.8270
>AT29375 WP_012701743.1 NC_021149:c3297170-3296883 [Azotobacter vinelandii CA]
MSKFFDDLMESVVQMDEIVRGERQPSREFTVDALQVKQIRKATGLSQAKFAAMIDVQVGTLRNWEQGRREPTGPAKALLR
AIHNDPEHVIRALAG
MSKFFDDLMESVVQMDEIVRGERQPSREFTVDALQVKQIRKATGLSQAKFAAMIDVQVGTLRNWEQGRREPTGPAKALLR
AIHNDPEHVIRALAG
Download Length: 288 bp
>AT29375 NC_021149:c3297170-3296883 [Azotobacter vinelandii CA]
ATGAGTAAGTTTTTCGACGACCTCATGGAAAGCGTCGTGCAAATGGACGAAATCGTTCGCGGCGAACGCCAGCCGTCCCG
CGAGTTCACCGTGGATGCCTTGCAGGTGAAGCAGATCCGCAAGGCCACCGGTCTTTCGCAGGCCAAGTTTGCCGCGATGA
TCGATGTGCAGGTGGGCACTCTGCGCAACTGGGAGCAAGGCCGCCGCGAGCCGACCGGCCCGGCCAAGGCTCTGCTGCGC
GCCATCCACAATGACCCGGAGCACGTCATTCGAGCGCTGGCGGGCTAA
ATGAGTAAGTTTTTCGACGACCTCATGGAAAGCGTCGTGCAAATGGACGAAATCGTTCGCGGCGAACGCCAGCCGTCCCG
CGAGTTCACCGTGGATGCCTTGCAGGTGAAGCAGATCCGCAAGGCCACCGGTCTTTCGCAGGCCAAGTTTGCCGCGATGA
TCGATGTGCAGGTGGGCACTCTGCGCAACTGGGAGCAAGGCCGCCGCGAGCCGACCGGCCCGGCCAAGGCTCTGCTGCGC
GCCATCCACAATGACCCGGAGCACGTCATTCGAGCGCTGGCGGGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|