Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1812436..1812938 Replicon chromosome
Accession NZ_LT906474
Organism Escherichia coli strain NCTC122

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag CKV98_RS09010 Protein ID WP_000767829.1
Coordinates 1812684..1812938 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag CKV98_RS09005 Protein ID WP_001259255.1
Coordinates 1812436..1812687 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV98_RS08975 1807614..1808681 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
CKV98_RS08980 1808681..1809751 - 1071 WP_000108940.1 histidinol-phosphate transaminase -
CKV98_RS08985 1809748..1811052 - 1305 WP_001317939.1 histidinol dehydrogenase -
CKV98_RS08990 1811058..1811957 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
CKV98_RS09000 1812103..1812153 - 51 WP_001364200.1 his operon leader peptide -
CKV98_RS09005 1812436..1812687 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
CKV98_RS09010 1812684..1812938 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
CKV98_RS09015 1813021..1813845 + 825 WP_000754737.1 SDR family oxidoreductase -
CKV98_RS09020 1813891..1814820 + 930 WP_081508817.1 LysR family transcriptional regulator -
CKV98_RS23540 1815035..1815097 + 63 WP_010723108.1 membrane protein YoeI -
CKV98_RS09025 1815087..1816445 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
CKV98_RS09030 1816624..1817682 + 1059 WP_000492305.1 transport protein YeeE -
CKV98_RS09035 1817696..1817923 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T293748 WP_000767829.1 NZ_LT906474:1812684-1812938 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT293748 WP_001259255.1 NZ_LT906474:1812436-1812687 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References