293748

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1812436..1812938 Replicon chromosome
Accession NZ_LT906474
Organism Escherichia coli strain NCTC122

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag CKV98_RS09010 Protein ID WP_000767829.1
Coordinates 1812684..1812938 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag CKV98_RS09005 Protein ID WP_001259255.1
Coordinates 1812436..1812687 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV98_RS08975 1807614..1808681 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
CKV98_RS08980 1808681..1809751 - 1071 WP_000108940.1 histidinol-phosphate transaminase -
CKV98_RS08985 1809748..1811052 - 1305 WP_001317939.1 histidinol dehydrogenase -
CKV98_RS08990 1811058..1811957 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
CKV98_RS09000 1812103..1812153 - 51 WP_001364200.1 his operon leader peptide -
CKV98_RS09005 1812436..1812687 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
CKV98_RS09010 1812684..1812938 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
CKV98_RS09015 1813021..1813845 + 825 WP_000754737.1 SDR family oxidoreductase -
CKV98_RS09020 1813891..1814820 + 930 WP_081508817.1 LysR family transcriptional regulator -
CKV98_RS23540 1815035..1815097 + 63 WP_010723108.1 membrane protein YoeI -
CKV98_RS09025 1815087..1816445 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
CKV98_RS09030 1816624..1817682 + 1059 WP_000492305.1 transport protein YeeE -
CKV98_RS09035 1817696..1817923 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-84)

Antitoxin

(1-73)


Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T293748 WP_000767829.1 NZ_LT906474:1812684-1812938 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp


Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT293748 WP_001259255.1 NZ_LT906474:1812436-1812687 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References