Detailed information of TA system TA293741

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2904225..2904813
• Replicon: chromosome
• Accession: NZ_LT906473
• Organism: Corynebacterium cystitidis strain NCTC11863

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: CKV99_RS13670
• Protein ID: WP_092258265.1
• Coordinates: 2904225..2904506 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CKV99_RS13675
• Protein ID: WP_197697197.1
• Coordinates: 2904514..2904813 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CKV99_RS13655	2900147..2901853	+	1707	WP_092258271.1	putative DNA binding domain-containing protein	-
CKV99_RS13660	2902270..2902947	+	678	WP_092258268.1	hypothetical protein	-
CKV99_RS13665	2903066..2904088	+	1023	Protein_2658	ATP-binding protein	-
CKV99_RS13670	2904225..2904506	+	282	WP_092258265.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CKV99_RS13675	2904514..2904813	+	300	WP_197697197.1	HigA family addiction module antidote protein	Antitoxin
CKV99_RS13680	2904870..2905604	-	735	WP_092258260.1	ABC transporter permease	-
CKV99_RS13685	2905604..2906353	-	750	WP_092258257.1	ABC transporter permease	-
CKV99_RS13690	2906350..2907261	-	912	WP_092258254.1	ABC transporter ATP-binding protein	-
CKV99_RS13695	2907322..2907993	-	672	WP_169872657.1	response regulator transcription factor	-
CKV99_RS13700	2907990..2909090	-	1101	WP_143063430.1	two-component sensor histidine kinase	-
CKV99_RS13705	2909244..2909498	-	255	WP_092258248.1	Txe/YoeB family addiction module toxin	-
CKV99_RS13710	2909509..2909769	-	261	WP_092258246.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (2-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (9-84)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10945.53 Da
• Isoelectric Point: 9.8327

>T293741 WP_092258265.1 NZ_LT906473:2904225-2904506 [Corynebacterium cystitidis]
VIESFRDKHTEDLWLNHRSAKIPSEILRKAVKQLKMLDFATSLDDLRIPPGNRLEKLTGDRKGQHSIRINHQWRVCFTWI
DGAARNVEIVDYH

Nucleotide

• Length: 282 bp

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11154.79 Da
• Isoelectric Point: 4.7815

>AT293741 WP_197697197.1 NZ_LT906473:2904514-2904813 [Corynebacterium cystitidis]
MTMTNNRMIFHPGEFLQEDFLEPLGLSQNALARAINVPPRRINEIVLGKRGISADTALRLARFFGNSPEFWMNMQKDYEL
ESARAAASDLDSIVPMEVA

Nucleotide

• Length: 300 bp