Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2904225..2904813 Replicon chromosome
Accession NZ_LT906473
Organism Corynebacterium cystitidis strain NCTC11863

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag CKV99_RS13670 Protein ID WP_092258265.1
Coordinates 2904225..2904506 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CKV99_RS13675 Protein ID WP_197697197.1
Coordinates 2904514..2904813 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV99_RS13655 2900147..2901853 + 1707 WP_092258271.1 putative DNA binding domain-containing protein -
CKV99_RS13660 2902270..2902947 + 678 WP_092258268.1 hypothetical protein -
CKV99_RS13665 2903066..2904088 + 1023 Protein_2658 ATP-binding protein -
CKV99_RS13670 2904225..2904506 + 282 WP_092258265.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CKV99_RS13675 2904514..2904813 + 300 WP_197697197.1 HigA family addiction module antidote protein Antitoxin
CKV99_RS13680 2904870..2905604 - 735 WP_092258260.1 ABC transporter permease -
CKV99_RS13685 2905604..2906353 - 750 WP_092258257.1 ABC transporter permease -
CKV99_RS13690 2906350..2907261 - 912 WP_092258254.1 ABC transporter ATP-binding protein -
CKV99_RS13695 2907322..2907993 - 672 WP_169872657.1 response regulator transcription factor -
CKV99_RS13700 2907990..2909090 - 1101 WP_143063430.1 two-component sensor histidine kinase -
CKV99_RS13705 2909244..2909498 - 255 WP_092258248.1 Txe/YoeB family addiction module toxin -
CKV99_RS13710 2909509..2909769 - 261 WP_092258246.1 type II toxin-antitoxin system prevent-host-death family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(9-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10945.53 Da        Isoelectric Point: 9.8327

>T293741 WP_092258265.1 NZ_LT906473:2904225-2904506 [Corynebacterium cystitidis]
VIESFRDKHTEDLWLNHRSAKIPSEILRKAVKQLKMLDFATSLDDLRIPPGNRLEKLTGDRKGQHSIRINHQWRVCFTWI
DGAARNVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11154.79 Da        Isoelectric Point: 4.7815

>AT293741 WP_197697197.1 NZ_LT906473:2904514-2904813 [Corynebacterium cystitidis]
MTMTNNRMIFHPGEFLQEDFLEPLGLSQNALARAINVPPRRINEIVLGKRGISADTALRLARFFGNSPEFWMNMQKDYEL
ESARAAASDLDSIVPMEVA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References