Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2807779..2808434 Replicon chromosome
Accession NZ_LT906471
Organism Bordetella pertussis strain NCTC13666

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag CKW12_RS13565 Protein ID WP_047122780.1
Coordinates 2808183..2808434 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag CKW12_RS13560 Protein ID WP_003809516.1
Coordinates 2807779..2808180 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW12_RS13530 2802962..2803984 - 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -
CKW12_RS13535 2804121..2805158 - 1038 WP_023853543.1 threonylcarbamoyl-AMP synthase -
CKW12_RS13540 2805178..2806368 - 1191 WP_010930406.1 5-(carboxyamino)imidazole ribonucleotide synthase -
CKW12_RS13545 2806371..2806886 - 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
CKW12_RS13550 2807036..2807515 - 480 WP_010930405.1 disulfide bond formation protein B -
CKW12_RS13555 2807523..2807759 - 237 WP_010930404.1 membrane protein -
CKW12_RS13560 2807779..2808180 - 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
CKW12_RS13565 2808183..2808434 - 252 WP_047122780.1 type II toxin-antitoxin system MqsR family toxin Toxin
CKW12_RS13570 2808489..2809370 - 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
CKW12_RS13575 2809595..2810041 + 447 WP_003819827.1 GFA family protein -
CKW12_RS13580 2810126..2811190 - 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
CKW12_RS13585 2811327..2811908 - 582 WP_019247931.1 molybdenum cofactor biosysynthesis protein -
CKW12_RS13590 2812143..2813273 + 1131 WP_010930401.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(10-82)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 8952.52 Da        Isoelectric Point: 9.7242

>T293737 WP_047122780.1 NZ_LT906471:c2808434-2808183 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Download         Length: 252 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT293737 WP_003809516.1 NZ_LT906471:c2808180-2807779 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References