Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 277017..277539 Replicon chromosome
Accession NZ_LT906460
Organism Staphylococcus simiae strain NCTC13838

Toxin (Protein)


Gene name yoeB Uniprot ID G5JF61
Locus tag CKV88_RS01120 Protein ID WP_002461590.1
Coordinates 277264..277539 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID G5JF62
Locus tag CKV88_RS01115 Protein ID WP_002461592.1
Coordinates 277017..277271 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV88_RS01090 272213..272887 + 675 WP_002461598.1 iron-sulfur cluster repair di-iron protein ScdA -
CKV88_RS01095 273095..274855 + 1761 WP_002461596.1 sensor histidine kinase -
CKV88_RS01100 274852..275592 + 741 WP_002461595.1 response regulator transcription factor LytR -
CKV88_RS01105 275715..276158 + 444 WP_050801493.1 antiholin-like murein hydrolase modulator LrgA -
CKV88_RS01110 276151..276852 + 702 WP_002461593.1 antiholin-like protein LrgB -
CKV88_RS01115 277017..277271 + 255 WP_002461592.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CKV88_RS01120 277264..277539 + 276 WP_002461590.1 Txe/YoeB family addiction module toxin Toxin
CKV88_RS01125 277698..279077 - 1380 WP_002461588.1 MFS transporter -
CKV88_RS01130 279426..280025 - 600 WP_002461586.1 hypothetical protein -
CKV88_RS01135 280124..280828 - 705 WP_002461585.1 GntR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10906.49 Da        Isoelectric Point: 9.8721

>T293715 WP_002461590.1 NZ_LT906460:277264-277539 [Staphylococcus simiae]
MTKLNITFSPDAFEDYKYWQKQDKKLLQKINSLIKSIQREGVLEGEGRPEPLRGDLKSYYSRRINHHEHRVVYKVTDSAI
LIASCRYHYYK

Download         Length: 276 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9407.38 Da        Isoelectric Point: 4.3138

>AT293715 WP_002461592.1 NZ_LT906460:277017-277271 [Staphylococcus simiae]
MTVITYSNARKNFRQLIDNVNDNAEAITITTNDRNAVLLSEADYNSIMETLYLQQSPANAKHLAQSIADLERGNSVKVDV
ESYD

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G5JF61

Antitoxin

Source ID Structure
AlphaFold DB G5JF62

References