Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 277017..277539 Replicon chromosome
Accession NZ_LT906460
Organism Staphylococcus simiae strain NCTC13838

Toxin (Protein)


Gene name yoeB Uniprot ID G5JF61
Locus tag CKV88_RS01120 Protein ID WP_002461590.1
Coordinates 277264..277539 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID G5JF62
Locus tag CKV88_RS01115 Protein ID WP_002461592.1
Coordinates 277017..277271 (+) Length 85 a.a.

Genomic Context

CKV88_RS01090CKV88_RS01095CKV88_RS01100CKV88_RS01105CKV88_RS01110CKV88_RS01115CKV88_RS01120CKV88_RS01125CKV88_RS01130CKV88_RS01135
Location: 272213..272887 (675 bp)
Type: Others
Protein ID: WP_002461598.1
Location: 273095..274855 (1761 bp)
Type: Others
Protein ID: WP_002461596.1
Location: 274852..275592 (741 bp)
Type: Others
Protein ID: WP_002461595.1
Location: 275715..276158 (444 bp)
Type: Others
Protein ID: WP_050801493.1
Location: 276151..276852 (702 bp)
Type: Others
Protein ID: WP_002461593.1
Location: 277017..277271 (255 bp)
Type: Antitoxin
Protein ID: WP_002461592.1
Location: 277264..277539 (276 bp)
Type: Toxin
Protein ID: WP_002461590.1
Location: 277698..279077 (1380 bp)
Type: Others
Protein ID: WP_002461588.1
Location: 279426..280025 (600 bp)
Type: Others
Protein ID: WP_002461586.1
Location: 280124..280828 (705 bp)
Type: Others
Protein ID: WP_002461585.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CKV88_RS01090272213..272887+675WP_002461598.1iron-sulfur cluster repair di-iron protein ScdA-
CKV88_RS01095273095..274855+1761WP_002461596.1sensor histidine kinase-
CKV88_RS01100274852..275592+741WP_002461595.1response regulator transcription factor LytR-
CKV88_RS01105275715..276158+444WP_050801493.1antiholin-like murein hydrolase modulator LrgA-
CKV88_RS01110276151..276852+702WP_002461593.1antiholin-like protein LrgB-
CKV88_RS01115277017..277271+255WP_002461592.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
CKV88_RS01120277264..277539+276WP_002461590.1Txe/YoeB family addiction module toxinToxin
CKV88_RS01125277698..279077-1380WP_002461588.1MFS transporter-
CKV88_RS01130279426..280025-600WP_002461586.1hypothetical protein-
CKV88_RS01135280124..280828-705WP_002461585.1GntR family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10906.49 Da        Isoelectric Point: 9.8721

>T293715 WP_002461590.1 NZ_LT906460:277264-277539 [Staphylococcus simiae]
MTKLNITFSPDAFEDYKYWQKQDKKLLQKINSLIKSIQREGVLEGEGRPEPLRGDLKSYYSRRINHHEHRVVYKVTDSAI
LIASCRYHYYK

Download         Length: 276 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9407.38 Da        Isoelectric Point: 4.3138

>AT293715 WP_002461592.1 NZ_LT906460:277017-277271 [Staphylococcus simiae]
MTVITYSNARKNFRQLIDNVNDNAEAITITTNDRNAVLLSEADYNSIMETLYLQQSPANAKHLAQSIADLERGNSVKVDV
ESYD

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBG5JF61

Antitoxin

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Source
ID
Structure
AlphaFold DBG5JF62

References