Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 638563..639806 Replicon chromosome
Accession NZ_LT906457
Organism Legionella spiritensis strain NCTC11990

Toxin (Protein)


Gene name HipT Uniprot ID A0A0W0YY80
Locus tag CKW05_RS02985 Protein ID WP_058484373.1
Coordinates 638868..639806 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A0W0YY94
Locus tag CKW05_RS02980 Protein ID WP_058484374.1
Coordinates 638563..638871 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW05_RS02960 634946..636559 - 1614 WP_058484378.1 HAMP domain-containing histidine kinase -
CKW05_RS02965 636556..637242 - 687 WP_058484377.1 response regulator transcription factor -
CKW05_RS02970 637395..638090 + 696 WP_058484376.1 hypothetical protein -
CKW05_RS02975 638339..638566 + 228 WP_058484375.1 helix-turn-helix transcriptional regulator -
CKW05_RS02980 638563..638871 + 309 WP_058484374.1 HipA N-terminal domain-containing protein Antitoxin
CKW05_RS02985 638868..639806 + 939 WP_058484373.1 lpg2370 family Dot/Icm T4SS effector Toxin
CKW05_RS02990 639853..640140 - 288 WP_157737709.1 hypothetical protein -
CKW05_RS02995 640335..643949 + 3615 WP_058484371.1 lamin tail domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(4-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35983.69 Da        Isoelectric Point: 9.4726

>T293713 WP_058484373.1 NZ_LT906457:638868-639806 [Legionella spiritensis]
MKRCPITYEKISNQENYSHRGLHLLSPQLKNLGPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKDGCFEIVDQNG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDRHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLRG
KKNNLTKSDFLNYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGLSFLSQPMQEKYLQLLDQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11548.35 Da        Isoelectric Point: 4.5881

>AT293713 WP_058484374.1 NZ_LT906457:638563-638871 [Legionella spiritensis]
MRKACVSVNGVKAGTLEELQGGTYQFTYFDDYRGAPVSLTMPLTKKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDRND
YFSQLIIVGQDVVGAVTIEELR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0YY80

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0YY94

References