Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 2046371..2047025 Replicon chromosome
Accession NZ_LT906456
Organism Actinobacillus suis strain NCTC12996

Toxin (Protein)


Gene name higB Uniprot ID K0G6E5
Locus tag CKV75_RS09490 Protein ID WP_015674148.1
Coordinates 2046663..2047025 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CKV75_RS09485 Protein ID WP_015674147.1
Coordinates 2046371..2046679 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV75_RS09460 2041516..2042082 - 567 WP_015674143.1 septal ring lytic transglycosylase RlpA family protein -
CKV75_RS09465 2042257..2043381 - 1125 WP_015674144.1 rod shape-determining protein RodA -
CKV75_RS09470 2043374..2045344 - 1971 WP_015674145.1 penicillin-binding protein 2 -
CKV75_RS09475 2045427..2045894 - 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
CKV75_RS09480 2045917..2046231 - 315 WP_015674146.1 ribosome silencing factor -
CKV75_RS09485 2046371..2046679 - 309 WP_015674147.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
CKV75_RS09490 2046663..2047025 - 363 WP_015674148.1 hypothetical protein Toxin
CKV75_RS09495 2047199..2049793 - 2595 WP_039195494.1 DNA mismatch repair protein MutS -
CKV75_RS09500 2049959..2050708 - 750 WP_015674150.1 amino acid ABC transporter ATP-binding protein -
CKV75_RS09505 2050730..2051446 - 717 WP_005605560.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14051.07 Da        Isoelectric Point: 10.2511

>T293709 WP_015674148.1 NZ_LT906456:c2047025-2046663 [Actinobacillus suis]
VKLVFVELPPFERYRQKHLSDEEYRHFQNELLENPNKGDLIQGTNGLRKIRIADMQRNKGKRGGARVIYYHIVNYSKILL
VTAYGKDEQSDLSNTERNMLANKVKRIVELEIRSSNGKTF

Download         Length: 363 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11652.60 Da        Isoelectric Point: 8.5450

>AT293709 WP_015674147.1 NZ_LT906456:c2046679-2046371 [Actinobacillus suis]
MGKLFDDLMEGLDAYEKHIQGKITLRTTVLEKPEPVELSPSEVKLIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QAVLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0G6E5

Antitoxin

Source ID Structure

References