293706

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1273290..1273935 Replicon chromosome
Accession NZ_LT906456
Organism Actinobacillus suis strain NCTC12996

Toxin (Protein)


Gene name higB Uniprot ID K0G4M5
Locus tag CKV75_RS05840 Protein ID WP_014991853.1
Coordinates 1273591..1273935 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CKV75_RS05835 Protein ID WP_014991852.1
Coordinates 1273290..1273586 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV75_RS05810 1268467..1269471 - 1005 WP_005600359.1 Holliday junction branch migration DNA helicase RuvB -
CKV75_RS05815 1269490..1270095 - 606 WP_014991848.1 Holliday junction branch migration protein RuvA -
CKV75_RS05820 1270237..1271004 - 768 WP_014991849.1 spermidine/putrescine ABC transporter permease PotC -
CKV75_RS05825 1271004..1271870 - 867 WP_014991850.1 spermidine/putrescine ABC transporter permease PotB -
CKV75_RS05830 1271857..1272972 - 1116 WP_014991851.1 spermidine/putrescine ABC transporter ATP-binding protein PotA -
CKV75_RS05835 1273290..1273586 - 297 WP_014991852.1 helix-turn-helix domain-containing protein Antitoxin
CKV75_RS05840 1273591..1273935 - 345 WP_014991853.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CKV75_RS05845 1274140..1276158 + 2019 WP_014991854.1 DNA helicase Rep -
CKV75_RS05850 1276247..1276999 - 753 WP_014991855.1 TatD family hydrolase -
CKV75_RS05855 1277093..1278244 - 1152 WP_039195223.1 methionine adenosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(39-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-83)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13348.34 Da        Isoelectric Point: 7.9875

>T293706 WP_014991853.1 NZ_LT906456:c1273935-1273591 [Actinobacillus suis]
MNSDEYLTFVEVGTFEEDRKQLMADDEYQLFQAYLLEHYELGDFISHTGGCQKIRWRLPENNKGKSAGVRIIYYVRSLTG
RIYLITMYGKSEKVNLNAREKAIMKKIISRLIGE

Download         Length: 345 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11129.00 Da        Isoelectric Point: 10.4778

>AT293706 WP_014991852.1 NZ_LT906456:c1273586-1273290 [Actinobacillus suis]
MEKRLFERLVQGLEEMVAIEKGEVEVPSHRIHAHKIPNTKAIRTQHHLKQAEFAQLLGVSTNLVQSWEIGRRVPNGAARK
LLAIIEQQPNLVPLLQSL

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0G4M5

Antitoxin

Source ID Structure

References