Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2874052..2875295 Replicon chromosome
Accession NZ_LT906442
Organism Legionella waltersii strain NCTC13017

Toxin (Protein)


Gene name HipT Uniprot ID A0A0W1A1C6
Locus tag CKW04_RS13285 Protein ID WP_058481808.1
Coordinates 2874357..2875295 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A0W1A1I4
Locus tag CKW04_RS13280 Protein ID WP_058481807.1
Coordinates 2874052..2874360 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW04_RS13250 2869490..2869873 - 384 Protein_2591 DUF4102 domain-containing protein -
CKW04_RS13255 2870308..2871068 - 761 Protein_2592 DEAD/DEAH box helicase family protein -
CKW04_RS13260 2871091..2872191 - 1101 WP_058481803.1 hypothetical protein -
CKW04_RS13265 2872562..2873044 - 483 Protein_2594 IS982 family transposase -
CKW04_RS13270 2873048..2873440 - 393 WP_133141277.1 hypothetical protein -
CKW04_RS13275 2873828..2874055 + 228 WP_058481806.1 helix-turn-helix transcriptional regulator -
CKW04_RS13280 2874052..2874360 + 309 WP_058481807.1 HipA N-terminal domain-containing protein Antitoxin
CKW04_RS13285 2874357..2875295 + 939 WP_058481808.1 lpg2370 family Dot/Icm T4SS effector Toxin
CKW04_RS13290 2875418..2875651 + 234 Protein_2599 DUF2779 domain-containing protein -
CKW04_RS13295 2875826..2876008 - 183 WP_058481810.1 hypothetical protein -
CKW04_RS13305 2876642..2877301 - 660 WP_058481946.1 hypothetical protein -
CKW04_RS13310 2877258..2877881 - 624 WP_133141276.1 hypothetical protein -
CKW04_RS13315 2878162..2878689 - 528 WP_058481811.1 hypothetical protein -
CKW04_RS13320 2878797..2879654 - 858 WP_058481812.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sidB / lem8 / lpg2370 2766469..2900080 133611


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36074.92 Da        Isoelectric Point: 9.2554

>T293689 WP_058481808.1 NZ_LT906442:2874357-2875295 [Legionella waltersii]
MKHCPITYEKISVQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGYFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQPMQEKYLELLELRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11625.51 Da        Isoelectric Point: 4.7719

>AT293689 WP_058481807.1 NZ_LT906442:2874052-2874360 [Legionella waltersii]
MRKAYVSVNGIRAGILEDLEGKKYQFTYLNDYQGAPVSLTMPLTNKIYNFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEELR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W1A1C6

Antitoxin

Source ID Structure
AlphaFold DB A0A0W1A1I4

References