Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1528107..1528771 Replicon chromosome
Accession NZ_LT906435
Organism Pandoraea sputorum strain NCTC13161

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CKW10_RS06845 Protein ID WP_072633217.1
Coordinates 1528107..1528385 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CKW10_RS06850 Protein ID WP_039397058.1
Coordinates 1528460..1528771 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW10_RS06840 1524651..1527974 + 3324 WP_084103522.1 error-prone DNA polymerase -
CKW10_RS06845 1528107..1528385 + 279 WP_072633217.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CKW10_RS06850 1528460..1528771 + 312 WP_039397058.1 HigA family addiction module antidote protein Antitoxin
CKW10_RS06855 1528799..1530169 - 1371 WP_039397060.1 purine permease -
CKW10_RS06860 1530702..1532201 - 1500 WP_052252587.1 HDOD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(28-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10608.14 Da        Isoelectric Point: 10.4098

>T293679 WP_072633217.1 NZ_LT906435:1528107-1528385 [Pandoraea sputorum]
MIENFKCRDTALLFSGRRVTRWRAVESAAIRKLQQLHAAATLSFLRAPPGNRLEALRGDRLGQYSIRINDQWRLCFRFDA
GTASDVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11294.20 Da        Isoelectric Point: 10.2163

>AT293679 WP_039397058.1 NZ_LT906435:1528460-1528771 [Pandoraea sputorum]
MTRQVPLATPGEILAQEWLGPMGISQYALAKAIDVPPRRINEIVLGKRAITVDTALRLGAFFGVDAQSWLNLQNQYDAEI
ARANMVDVLKTIKHRARALLAAA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References