Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1357975..1358540 Replicon chromosome
Accession NZ_LT906434
Organism Neisseria zoodegmatis strain NCTC12230

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CKV66_RS06375 Protein ID WP_085363808.1
Coordinates 1358262..1358540 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag CKV66_RS06370 Protein ID WP_085363831.1
Coordinates 1357975..1358250 (-) Length 92 a.a.

Genomic Context

CKV66_RS06350CKV66_RS12180CKV66_RS06390CKV66_RS06395CKV66_RS06400CKV66_RS06355CKV66_RS06360CKV66_RS06365CKV66_RS06370CKV66_RS06375CKV66_RS06385
Location: 1353069..1353455 (387 bp)
Type: Others
Protein ID: WP_085363812.1
Location: 1357408..1357572 (165 bp)
Type: Others
Protein ID: WP_157739153.1
Location: 1360623..1361432 (810 bp)
Type: Others
Protein ID: WP_158087794.1
Location: 1361774..1361992 (219 bp)
Type: Others
Protein ID: WP_085363804.1
Location: 1362004..1362591 (588 bp)
Type: Others
Protein ID: WP_085363803.1
Location: 1353594..1354430 (837 bp)
Type: Others
Protein ID: WP_085363811.1
Location: 1354516..1355991 (1476 bp)
Type: Others
Protein ID: WP_085363810.1
Location: 1356242..1357249 (1008 bp)
Type: Others
Protein ID: WP_085363809.1
Location: 1357975..1358250 (276 bp)
Type: Antitoxin
Protein ID: WP_085363831.1
Location: 1358262..1358540 (279 bp)
Type: Toxin
Protein ID: WP_085363808.1
Location: 1359004..1360383 (1380 bp)
Type: Others
Protein ID: WP_085363806.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CKV66_RS063501353069..1353455+387WP_085363812.1MliC family protein-
CKV66_RS063551353594..1354430-837WP_085363811.1hypothetical protein-
CKV66_RS063601354516..1355991-1476WP_085363810.1anthranilate synthase component I-
CKV66_RS063651356242..1357249-1008WP_085363809.1IS5 family transposase-
CKV66_RS121801357408..1357572+165WP_157739153.1hypothetical protein-
CKV66_RS063701357975..1358250-276WP_085363831.1HigA family addiction module antidote proteinAntitoxin
CKV66_RS063751358262..1358540-279WP_085363808.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CKV66_RS063851359004..1360383-1380WP_085363806.1DNA repair protein RadA-
CKV66_RS063901360623..1361432+810WP_158087794.1sel1 repeat family protein-
CKV66_RS063951361774..1361992+219WP_085363804.1sulfurtransferase TusA family protein-
CKV66_RS064001362004..1362591+588WP_085363803.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element-pilW1329373..1513637184264
-flankIS/Tn--1356242..13572491007


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-59)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10532.90 Da        Isoelectric Point: 10.2615

>T293673 WP_085363808.1 NZ_LT906434:c1358540-1358262 [Neisseria zoodegmatis]
MIKSFKHKGLAIFFETGNKAGIQANHAEKLKLQLSALNRATSPRDVNAPGWQLHQLSGNLKDHWSIKVNGNWRITFRFNG
NDVEVVDYQDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10026.56 Da        Isoelectric Point: 7.2757

>AT293673 WP_085363831.1 NZ_LT906434:c1358250-1357975 [Neisseria zoodegmatis]
MHNPPHPGLVLREYLAETSVTEAAKRLGVTRAALSRVLNSKAAISAEMAVRLSILLGTSSQMWLGMQSDYDLWQAEQKPH
DFVVPLSTAYC

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References