Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1357975..1358540 Replicon chromosome
Accession NZ_LT906434
Organism Neisseria zoodegmatis strain NCTC12230

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CKV66_RS06375 Protein ID WP_085363808.1
Coordinates 1358262..1358540 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag CKV66_RS06370 Protein ID WP_085363831.1
Coordinates 1357975..1358250 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV66_RS06350 1353069..1353455 + 387 WP_085363812.1 MliC family protein -
CKV66_RS06355 1353594..1354430 - 837 WP_085363811.1 hypothetical protein -
CKV66_RS06360 1354516..1355991 - 1476 WP_085363810.1 anthranilate synthase component I -
CKV66_RS06365 1356242..1357249 - 1008 WP_085363809.1 IS5 family transposase -
CKV66_RS12180 1357408..1357572 + 165 WP_157739153.1 hypothetical protein -
CKV66_RS06370 1357975..1358250 - 276 WP_085363831.1 HigA family addiction module antidote protein Antitoxin
CKV66_RS06375 1358262..1358540 - 279 WP_085363808.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CKV66_RS06385 1359004..1360383 - 1380 WP_085363806.1 DNA repair protein RadA -
CKV66_RS06390 1360623..1361432 + 810 WP_158087794.1 sel1 repeat family protein -
CKV66_RS06395 1361774..1361992 + 219 WP_085363804.1 sulfurtransferase TusA family protein -
CKV66_RS06400 1362004..1362591 + 588 WP_085363803.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - pilW 1329373..1513637 184264
- flank IS/Tn - - 1356242..1357249 1007


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-59)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10532.90 Da        Isoelectric Point: 10.2615

>T293673 WP_085363808.1 NZ_LT906434:c1358540-1358262 [Neisseria zoodegmatis]
MIKSFKHKGLAIFFETGNKAGIQANHAEKLKLQLSALNRATSPRDVNAPGWQLHQLSGNLKDHWSIKVNGNWRITFRFNG
NDVEVVDYQDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10026.56 Da        Isoelectric Point: 7.2757

>AT293673 WP_085363831.1 NZ_LT906434:c1358250-1357975 [Neisseria zoodegmatis]
MHNPPHPGLVLREYLAETSVTEAAKRLGVTRAALSRVLNSKAAISAEMAVRLSILLGTSSQMWLGMQSDYDLWQAEQKPH
DFVVPLSTAYC

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References