293645

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2654025..2654527 Replicon chromosome
Accession NZ_LT903847
Organism Escherichia coli O127:H6 isolate EPEC1

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag BQ9550_RS13700 Protein ID WP_000767829.1
Coordinates 2654273..2654527 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag BQ9550_RS13695 Protein ID WP_001259255.1
Coordinates 2654025..2654276 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ9550_RS13665 2649203..2650270 - 1068 WP_000080126.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
BQ9550_RS13670 2650270..2651340 - 1071 WP_000108994.1 histidinol-phosphate transaminase -
BQ9550_RS13675 2651337..2652641 - 1305 WP_001339747.1 histidinol dehydrogenase -
BQ9550_RS13680 2652647..2653546 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
BQ9550_RS13690 2653692..2653742 - 51 WP_001364200.1 his operon leader peptide -
BQ9550_RS13695 2654025..2654276 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
BQ9550_RS13700 2654273..2654527 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
BQ9550_RS13705 2654610..2655434 + 825 WP_000754737.1 SDR family oxidoreductase -
BQ9550_RS13710 2655480..2656409 + 930 WP_000803379.1 LysR family transcriptional regulator -
BQ9550_RS13715 2656624..2656686 + 63 WP_010723108.1 membrane protein YoeI -
BQ9550_RS13720 2656676..2658034 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T293645 WP_000767829.1 NZ_LT903847:2654273-2654527 [Escherichia coli O127:H6]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT293645 WP_001259255.1 NZ_LT903847:2654025-2654276 [Escherichia coli O127:H6]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References