Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 574450..575052 Replicon chromosome
Accession NZ_LT903847
Organism Escherichia coli O127:H6 isolate EPEC1

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag BQ9550_RS02895 Protein ID WP_000897305.1
Coordinates 574741..575052 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BQ9550_RS02890 Protein ID WP_000356397.1
Coordinates 574450..574740 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ9550_RS02870 570943..571845 + 903 WP_000331385.1 formate dehydrogenase O subunit beta -
BQ9550_RS02875 571842..572477 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
BQ9550_RS02880 572474..573403 + 930 WP_000027712.1 formate dehydrogenase accessory protein FdhE -
BQ9550_RS02885 573627..573845 - 219 WP_001314326.1 ribbon-helix-helix domain-containing protein -
BQ9550_RS02890 574450..574740 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
BQ9550_RS02895 574741..575052 - 312 WP_000897305.1 hypothetical protein Toxin
BQ9550_RS02900 575281..576189 + 909 WP_001386513.1 alpha/beta hydrolase -
BQ9550_RS02905 576253..577194 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
BQ9550_RS02910 577239..577676 - 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
BQ9550_RS02915 577673..578545 - 873 WP_000920747.1 virulence factor BrkB family protein -
BQ9550_RS02920 578539..579138 - 600 WP_001298594.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T293639 WP_000897305.1 NZ_LT903847:c575052-574741 [Escherichia coli O127:H6]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT293639 WP_000356397.1 NZ_LT903847:c574740-574450 [Escherichia coli O127:H6]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References