Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3701151..3701692 Replicon chromosome
Accession NZ_LT883142
Organism Escherichia coli isolate 6666666.257727.embl

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag EC1094V2_RS20790 Protein ID WP_000615976.1
Coordinates 3701414..3701692 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag EC1094V2_RS20785 Protein ID WP_000729704.1
Coordinates 3701151..3701411 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC1094V2_RS20765 3696834..3697619 - 786 WP_000207587.1 putative lateral flagellar export/assembly protein LafU -
EC1094V2_RS20770 3697591..3699303 + 1713 Protein_3495 flagellar biosynthesis protein FlhA -
EC1094V2_RS20775 3699567..3700016 - 450 WP_096321275.1 REP-associated tyrosine transposase RayT -
EC1094V2_RS20780 3700192..3700965 - 774 WP_015675129.1 C40 family peptidase -
EC1094V2_RS20785 3701151..3701411 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
EC1094V2_RS20790 3701414..3701692 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
EC1094V2_RS20795 3701848..3702588 + 741 WP_001225679.1 murein L,D-transpeptidase -
EC1094V2_RS20800 3702559..3703326 - 768 WP_000333379.1 class II glutamine amidotransferase -
EC1094V2_RS20805 3703532..3704110 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T293604 WP_000615976.1 NZ_LT883142:3701414-3701692 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT293604 WP_000729704.1 NZ_LT883142:3701151-3701411 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References