Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1753166..1753668 Replicon chromosome
Accession NZ_LT883142
Organism Escherichia coli isolate 6666666.257727.embl

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EC1094V2_RS10495 Protein ID WP_000767829.1
Coordinates 1753414..1753668 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EC1094V2_RS10490 Protein ID WP_001259255.1
Coordinates 1753166..1753417 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC1094V2_RS10460 1748343..1749410 - 1068 WP_000080133.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EC1094V2_RS10465 1749410..1750480 - 1071 WP_001099215.1 histidinol-phosphate transaminase -
EC1094V2_RS10470 1750477..1751781 - 1305 WP_001360321.1 histidinol dehydrogenase -
EC1094V2_RS10475 1751787..1752686 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EC1094V2_RS10485 1752832..1752882 - 51 WP_001364200.1 his operon leader peptide -
EC1094V2_RS10490 1753166..1753417 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EC1094V2_RS10495 1753414..1753668 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EC1094V2_RS10500 1753751..1754575 + 825 WP_000754762.1 SDR family oxidoreductase -
EC1094V2_RS10505 1754621..1755550 + 930 WP_000803360.1 LysR family transcriptional regulator -
EC1094V2_RS10510 1755765..1755827 + 63 WP_010723108.1 membrane protein YoeI -
EC1094V2_RS10515 1755817..1757175 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EC1094V2_RS10520 1757354..1758412 + 1059 WP_000492305.1 transport protein YeeE -
EC1094V2_RS10525 1758426..1758653 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T293593 WP_000767829.1 NZ_LT883142:1753414-1753668 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT293593 WP_001259255.1 NZ_LT883142:1753166-1753417 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References