Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 508333..509132 Replicon chromosome
Accession NZ_LT883142
Organism Escherichia coli isolate 6666666.257727.embl

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag EC1094V2_RS04270 Protein ID WP_000347251.1
Coordinates 508333..508797 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag EC1094V2_RS04275 Protein ID WP_001307405.1
Coordinates 508797..509132 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC1094V2_RS04235 503334..503768 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
EC1094V2_RS04240 503786..504664 - 879 WP_001300474.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
EC1094V2_RS04245 504654..505433 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
EC1094V2_RS04250 505444..505917 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
EC1094V2_RS04255 505940..507220 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
EC1094V2_RS04265 507469..508278 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
EC1094V2_RS04270 508333..508797 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
EC1094V2_RS04275 508797..509132 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
EC1094V2_RS04280 509281..510852 - 1572 WP_001273763.1 galactarate dehydratase -
EC1094V2_RS04285 511227..512561 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
EC1094V2_RS04290 512577..513347 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T293588 WP_000347251.1 NZ_LT883142:c508797-508333 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT293588 WP_001307405.1 NZ_LT883142:c509132-508797 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References