Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1832515..1833017 Replicon chromosome
Accession NZ_LT838200
Organism Escherichia coli isolate WI2 isolate

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag DSZ51_RS09225 Protein ID WP_000767829.1
Coordinates 1832763..1833017 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag DSZ51_RS09220 Protein ID WP_001259255.1
Coordinates 1832515..1832766 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSZ51_RS09190 1827692..1828759 - 1068 WP_000080055.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
DSZ51_RS09195 1828759..1829829 - 1071 WP_000108933.1 histidinol-phosphate transaminase -
DSZ51_RS09200 1829826..1831130 - 1305 WP_001352244.1 histidinol dehydrogenase -
DSZ51_RS09205 1831136..1832035 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
DSZ51_RS09215 1832181..1832231 - 51 WP_001364200.1 his operon leader peptide -
DSZ51_RS09220 1832515..1832766 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
DSZ51_RS09225 1832763..1833017 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
DSZ51_RS09230 1833100..1833924 + 825 WP_000754737.1 SDR family oxidoreductase -
DSZ51_RS09235 1833970..1834899 + 930 WP_000803366.1 LysR family transcriptional regulator -
DSZ51_RS09240 1835114..1835176 + 63 WP_010723108.1 membrane protein YoeI -
DSZ51_RS09245 1835166..1836524 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
DSZ51_RS09250 1836703..1837761 + 1059 WP_000492346.1 transport protein YeeE -
DSZ51_RS09255 1837775..1838002 + 228 WP_000985272.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T293538 WP_000767829.1 NZ_LT838200:1832763-1833017 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT293538 WP_001259255.1 NZ_LT838200:1832515-1832766 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References