Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 607988..608787 Replicon chromosome
Accession NZ_LT838200
Organism Escherichia coli isolate WI2 isolate

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag DSZ51_RS03155 Protein ID WP_000347251.1
Coordinates 607988..608452 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag DSZ51_RS03160 Protein ID WP_001307405.1
Coordinates 608452..608787 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSZ51_RS03120 602989..603423 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
DSZ51_RS03125 603441..604319 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
DSZ51_RS03130 604309..605088 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
DSZ51_RS03135 605099..605572 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
DSZ51_RS03140 605595..606875 - 1281 WP_000681905.1 tagatose-bisphosphate aldolase subunit KbaZ -
DSZ51_RS03150 607124..607933 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
DSZ51_RS03155 607988..608452 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
DSZ51_RS03160 608452..608787 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
DSZ51_RS03165 608936..610507 - 1572 WP_001273753.1 galactarate dehydratase -
DSZ51_RS03170 610882..612216 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
DSZ51_RS03175 612232..613002 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T293533 WP_000347251.1 NZ_LT838200:c608452-607988 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT293533 WP_001307405.1 NZ_LT838200:c608787-608452 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References