Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1832507..1833009 Replicon chromosome
Accession NZ_LT838196
Organism Escherichia coli isolate WI1 isolate

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag WI2_RS09200 Protein ID WP_000767829.1
Coordinates 1832755..1833009 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag WI2_RS09195 Protein ID WP_001259255.1
Coordinates 1832507..1832758 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WI2_RS09165 1827684..1828751 - 1068 WP_000080055.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
WI2_RS09170 1828751..1829821 - 1071 WP_000108933.1 histidinol-phosphate transaminase -
WI2_RS09175 1829818..1831122 - 1305 WP_001352244.1 histidinol dehydrogenase -
WI2_RS09180 1831128..1832027 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
WI2_RS09190 1832173..1832223 - 51 WP_001364200.1 his operon leader peptide -
WI2_RS09195 1832507..1832758 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
WI2_RS09200 1832755..1833009 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
WI2_RS09205 1833092..1833916 + 825 WP_000754737.1 SDR family oxidoreductase -
WI2_RS09210 1833962..1834891 + 930 WP_000803366.1 LysR family transcriptional regulator -
WI2_RS26215 1835106..1835168 + 63 WP_010723108.1 membrane protein YoeI -
WI2_RS09215 1835158..1836516 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
WI2_RS09220 1836695..1837753 + 1059 WP_000492346.1 transport protein YeeE -
WI2_RS09225 1837767..1837994 + 228 WP_000985272.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T293513 WP_000767829.1 NZ_LT838196:1832755-1833009 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT293513 WP_001259255.1 NZ_LT838196:1832507-1832758 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References