Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 723945..724638 Replicon chromosome
Accession NZ_LT838196
Organism Escherichia coli isolate WI1 isolate

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag WI2_RS03775 Protein ID WP_000415584.1
Coordinates 723945..724241 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag WI2_RS03780 Protein ID WP_000650107.1
Coordinates 724243..724638 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WI2_RS03740 719033..719347 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
WI2_RS03745 719378..719959 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
WI2_RS03750 720278..720610 + 333 WP_000917684.1 DUF2645 family protein -
WI2_RS03755 720656..722005 - 1350 WP_000673403.1 two-component system sensor histidine kinase QseC -
WI2_RS03760 722002..722661 - 660 WP_001221493.1 two-component system response regulator QseB -
WI2_RS03765 722813..723205 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
WI2_RS03770 723258..723740 + 483 WP_000183505.1 transcriptional regulator -
WI2_RS03775 723945..724241 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
WI2_RS03780 724243..724638 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
WI2_RS03785 724771..726378 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
WI2_RS03790 726516..728774 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T293510 WP_000415584.1 NZ_LT838196:723945-724241 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT293510 WP_000650107.1 NZ_LT838196:724243-724638 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References