Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-OrzO/SymE(toxin)
Location 4250415..4250827 Replicon chromosome
Accession NZ_LT795502
Organism Escherichia coli strain KV7 isolate KV7

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag KJB12_RS20185 Protein ID WP_000132601.1
Coordinates 4250486..4250827 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name OrzO
Locus tag -
Coordinates 4250415..4250491 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJB12_RS20175 (4247278) 4247278..4248867 + 1590 WP_001063204.1 type I restriction-modification system methyltransferase -
KJB12_RS20180 (4248864) 4248864..4250258 + 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
- (4250415) 4250415..4250491 - 77 NuclAT_12 - Antitoxin
- (4250415) 4250415..4250491 - 77 NuclAT_12 - Antitoxin
- (4250415) 4250415..4250491 - 77 NuclAT_12 - Antitoxin
- (4250415) 4250415..4250491 - 77 NuclAT_12 - Antitoxin
- (4250415) 4250415..4250491 - 77 NuclAT_13 - Antitoxin
- (4250415) 4250415..4250491 - 77 NuclAT_13 - Antitoxin
- (4250415) 4250415..4250491 - 77 NuclAT_13 - Antitoxin
- (4250415) 4250415..4250491 - 77 NuclAT_13 - Antitoxin
KJB12_RS20185 (4250486) 4250486..4250827 + 342 WP_000132601.1 endoribonuclease SymE Toxin
KJB12_RS20190 (4250989) 4250989..4252368 + 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
KJB12_RS20195 (4252368) 4252368..4253414 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4248864..4263781 14917


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T293475 WP_000132601.1 NZ_LT795502:4250486-4250827 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT293475 NZ_LT795502:c4250491-4250415 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References