Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3901081..3901622 Replicon chromosome
Accession NZ_LT795502
Organism Escherichia coli strain KV7 isolate KV7

Toxin (Protein)


Gene name yafQ Uniprot ID U9XF38
Locus tag KJB12_RS18600 Protein ID WP_001695460.1
Coordinates 3901344..3901622 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag KJB12_RS18595 Protein ID WP_000729704.1
Coordinates 3901081..3901341 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJB12_RS18585 (3899348) 3899348..3899845 - 498 WP_000006265.1 REP-associated tyrosine transposase RayT -
KJB12_RS18590 (3900122) 3900122..3900871 - 750 WP_001695461.1 C40 family peptidase -
KJB12_RS18595 (3901081) 3901081..3901341 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
KJB12_RS18600 (3901344) 3901344..3901622 + 279 WP_001695460.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
KJB12_RS18605 (3901778) 3901778..3902518 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
KJB12_RS18610 (3902489) 3902489..3903256 - 768 WP_000333379.1 class II glutamine amidotransferase -
KJB12_RS27145 (3903323) 3903323..3903456 + 134 Protein_3663 hypothetical protein -
KJB12_RS18615 (3903462) 3903462..3904040 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 3898745..3909843 11098


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T293474 WP_001695460.1 NZ_LT795502:3901344-3901622 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYIMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT293474 WP_000729704.1 NZ_LT795502:3901081-3901341 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XF38

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References