293465

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1865277..1865779 Replicon chromosome
Accession NZ_LT795502
Organism Escherichia coli strain KV7 isolate KV7

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag KJB12_RS08785 Protein ID WP_000767829.1
Coordinates 1865525..1865779 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag KJB12_RS08780 Protein ID WP_001259255.1
Coordinates 1865277..1865528 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJB12_RS08755 (1860454) 1860454..1861521 - 1068 WP_213222151.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
KJB12_RS08760 (1861521) 1861521..1862591 - 1071 WP_024230221.1 histidinol-phosphate transaminase -
KJB12_RS08765 (1862588) 1862588..1863892 - 1305 WP_213222152.1 histidinol dehydrogenase -
KJB12_RS08770 (1863898) 1863898..1864797 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
KJB12_RS08775 (1864943) 1864943..1864993 - 51 WP_001364200.1 his operon leader peptide -
KJB12_RS08780 (1865277) 1865277..1865528 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
KJB12_RS08785 (1865525) 1865525..1865779 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
KJB12_RS08790 (1865862) 1865862..1866686 + 825 WP_213222153.1 SDR family oxidoreductase -
KJB12_RS08795 (1866732) 1866732..1867661 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
KJB12_RS08800 (1867876) 1867876..1867938 + 63 WP_010723108.1 membrane protein YoeI -
KJB12_RS08805 (1867928) 1867928..1869286 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
KJB12_RS08810 (1869465) 1869465..1870523 + 1059 WP_065227176.1 thiosulfate utilization transporter TsuA/YeeE -
KJB12_RS08815 (1870537) 1870537..1870764 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T293465 WP_000767829.1 NZ_LT795502:1865525-1865779 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT293465 WP_001259255.1 NZ_LT795502:1865277-1865528 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References