Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 625064..625863 Replicon chromosome
Accession NZ_LT795502
Organism Escherichia coli strain KV7 isolate KV7

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag KJB12_RS03025 Protein ID WP_000347273.1
Coordinates 625064..625528 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag KJB12_RS03030 Protein ID WP_001307405.1
Coordinates 625528..625863 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJB12_RS02995 (620065) 620065..620499 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
KJB12_RS03000 (620517) 620517..621395 - 879 Protein_590 PTS N-acetylgalactosamine transporter subunit IID -
KJB12_RS03005 (621385) 621385..622164 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
KJB12_RS03010 (622175) 622175..622648 - 474 WP_001626031.1 PTS N-acetylgalactosamine transporter subunit IIB -
KJB12_RS03015 (622671) 622671..623951 - 1281 WP_000681939.1 tagatose-bisphosphate aldolase subunit KbaZ -
KJB12_RS03020 (624200) 624200..625009 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
KJB12_RS03025 (625064) 625064..625528 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
KJB12_RS03030 (625528) 625528..625863 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
KJB12_RS03035 (626012) 626012..627583 - 1572 WP_001273763.1 galactarate dehydratase -
KJB12_RS03040 (627958) 627958..629292 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
KJB12_RS03045 (629308) 629308..630078 + 771 WP_001058233.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T293461 WP_000347273.1 NZ_LT795502:c625528-625064 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT293461 WP_001307405.1 NZ_LT795502:c625863-625528 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References