Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1959255..1959768 Replicon chromosome
Accession NZ_LT714196
Organism Streptococcus agalactiae isolate BM110

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag BQ8897_RS10315 Protein ID WP_000481712.1
Coordinates 1959255..1959509 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag BQ8897_RS10320 Protein ID WP_000387490.1
Coordinates 1959502..1959768 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ8897_RS10295 1955019..1957520 - 2502 WP_000239414.1 ATP-binding protein -
BQ8897_RS10300 1957541..1957951 - 411 WP_000390747.1 conjugal transfer protein -
BQ8897_RS10305 1957962..1958228 - 267 WP_001055037.1 hypothetical protein -
BQ8897_RS10310 1958249..1959202 - 954 WP_000565540.1 conjugal transfer protein -
BQ8897_RS10315 1959255..1959509 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
BQ8897_RS10320 1959502..1959768 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BQ8897_RS10325 1959913..1960386 - 474 WP_000560386.1 hypothetical protein -
BQ8897_RS10330 1960394..1960876 - 483 WP_000383283.1 antirestriction protein ArdA -
BQ8897_RS10335 1960929..1961201 - 273 WP_000017154.1 hypothetical protein -
BQ8897_RS10340 1961336..1961905 - 570 WP_000010056.1 hypothetical protein -
BQ8897_RS10345 1961908..1963257 - 1350 WP_000491712.1 AAA family ATPase -
BQ8897_RS10350 1963454..1963753 - 300 WP_000737133.1 helix-turn-helix domain-containing protein -
BQ8897_RS10355 1963737..1964114 - 378 WP_000287186.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T293454 WP_000481712.1 NZ_LT714196:c1959509-1959255 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT293454 WP_000387490.1 NZ_LT714196:c1959768-1959502 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References