293433

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5257182..5257777 Replicon chromosome
Accession NZ_LT673656
Organism Pseudomonas aeruginosa isolate PcyII-10

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PERCYII10_RS24800 Protein ID WP_003113526.1
Coordinates 5257499..5257777 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PERCYII10_RS24795 Protein ID WP_003113527.1
Coordinates 5257182..5257487 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PERCYII10_RS24780 5252458..5255085 - 2628 WP_033976135.1 protein kinase family protein -
PERCYII10_RS29785 5255158..5255934 - 777 WP_154070686.1 hypothetical protein -
PERCYII10_RS24785 5256136..5256423 - 288 WP_076939040.1 barstar family protein -
PERCYII10_RS24790 5256420..5256812 - 393 WP_154070687.1 hypothetical protein -
PERCYII10_RS24795 5257182..5257487 - 306 WP_003113527.1 HigA family addiction module antidote protein Antitoxin
PERCYII10_RS24800 5257499..5257777 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PERCYII10_RS24810 5258106..5260334 + 2229 WP_023086667.1 TonB-dependent receptor -
PERCYII10_RS24815 5260404..5261051 - 648 WP_003095021.1 carbonate dehydratase -
PERCYII10_RS24820 5261113..5262351 - 1239 WP_019681675.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T293433 WP_003113526.1 NZ_LT673656:c5257777-5257499 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT293433 WP_003113527.1 NZ_LT673656:c5257487-5257182 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References