Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2508172..2508695 Replicon chromosome
Accession NZ_LT671859
Organism Staphylococcus aureus isolate Clinical isolate

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag EDCC5055_RS13195 Protein ID WP_000074048.1
Coordinates 2508172..2508438 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag EDCC5055_RS13200 Protein ID WP_000587616.1
Coordinates 2508438..2508695 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EDCC5055_RS13175 2503479..2504666 - 1188 WP_000026194.1 MFS transporter -
EDCC5055_RS13180 2505062..2505838 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
EDCC5055_RS13185 2505831..2506493 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
EDCC5055_RS13190 2506741..2507817 - 1077 WP_001076686.1 M42 family metallopeptidase -
EDCC5055_RS13195 2508172..2508438 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
EDCC5055_RS13200 2508438..2508695 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EDCC5055_RS13210 2509054..2509509 + 456 WP_000732082.1 DUF1307 domain-containing protein -
EDCC5055_RS13215 2509677..2511254 - 1578 WP_015581911.1 FMN-binding glutamate synthase family protein -
EDCC5055_RS13220 2511449..2512198 + 750 WP_000072443.1 hypothetical protein -
EDCC5055_RS13225 2512422..2513615 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T293428 WP_000074048.1 NZ_LT671859:c2508438-2508172 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT293428 WP_000587616.1 NZ_LT671859:c2508695-2508438 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References