Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2476672..2476856 Replicon chromosome
Accession NZ_LT671859
Organism Staphylococcus aureus isolate Clinical isolate

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag EDCC5055_RS13030 Protein ID WP_000482650.1
Coordinates 2476749..2476856 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2476672..2476732 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EDCC5055_RS13000 2472202..2472369 - 168 WP_001790576.1 hypothetical protein -
EDCC5055_RS13010 2472600..2474333 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
EDCC5055_RS13015 2474358..2476121 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2476672..2476732 + 61 - - Antitoxin
EDCC5055_RS13030 2476749..2476856 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
EDCC5055_RS13035 2476990..2477376 - 387 WP_000779358.1 flippase GtxA -
EDCC5055_RS13040 2477644..2478786 + 1143 WP_001176863.1 glycerate kinase -
EDCC5055_RS13045 2478846..2479505 + 660 WP_000831298.1 membrane protein -
EDCC5055_RS13050 2479687..2480898 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
EDCC5055_RS13055 2481021..2481494 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T293427 WP_000482650.1 NZ_LT671859:c2476856-2476749 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT293427 NZ_LT671859:2476672-2476732 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References