Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2451323..2451840 Replicon chromosome
Accession NZ_LT671859
Organism Staphylococcus aureus isolate Clinical isolate

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag EDCC5055_RS12865 Protein ID WP_000113262.1
Coordinates 2451323..2451589 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag EDCC5055_RS12870 Protein ID WP_000584499.1
Coordinates 2451589..2451840 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EDCC5055_RS12840 2446749..2447285 - 537 WP_015581908.1 GNAT family N-acetyltransferase -
EDCC5055_RS12845 2447518..2448342 - 825 WP_000572040.1 formate/nitrite transporter family protein -
EDCC5055_RS12850 2448559..2448741 - 183 WP_000230294.1 hypothetical protein -
EDCC5055_RS12855 2448825..2449292 - 468 WP_000153344.1 SRPBCC domain-containing protein -
EDCC5055_RS12860 2449478..2451028 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
EDCC5055_RS15050 2451217..2451288 - 72 Protein_2366 hypothetical protein -
EDCC5055_RS12865 2451323..2451589 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
EDCC5055_RS12870 2451589..2451840 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EDCC5055_RS12875 2452005..2452106 - 102 WP_001791744.1 hypothetical protein -
EDCC5055_RS12880 2452113..2452712 - 600 WP_000162813.1 DsbA family protein -
EDCC5055_RS12885 2452731..2453090 - 360 WP_031865816.1 DUF4467 domain-containing protein -
EDCC5055_RS12890 2453345..2454595 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
EDCC5055_RS12895 2454692..2455423 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
EDCC5055_RS12900 2455420..2456139 - 720 WP_015581909.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T293426 WP_000113262.1 NZ_LT671859:c2451589-2451323 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT293426 WP_000584499.1 NZ_LT671859:c2451840-2451589 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References