Detailed information of TA system TA293425

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2186370..2186587
• Replicon: chromosome
• Accession: NZ_LT671859
• Organism: Staphylococcus aureus isolate Clinical isolate

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: EDCC5055_RS11450
• Protein ID: WP_001802298.1
• Coordinates: 2186483..2186587 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2186370..2186425 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EDCC5055_RS11430	2182507..2183172	-	666	WP_001024094.1	SDR family oxidoreductase	-
EDCC5055_RS11435	2183324..2183644	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
EDCC5055_RS11440	2183646..2184626	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
EDCC5055_RS11445	2184892..2185983	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2186370..2186425	+	56	-	-	Antitoxin
EDCC5055_RS11450	2186483..2186587	-	105	WP_001802298.1	hypothetical protein	Toxin
EDCC5055_RS15040	2186748..2187231	-	484	Protein_2100	recombinase family protein	-
EDCC5055_RS11460	2187274..2188410	-	1137	WP_000115564.1	SAP domain-containing protein	-
EDCC5055_RS11465	2188699..2188791	+	93	WP_001790138.1	hypothetical protein	-
EDCC5055_RS11470	2189496..2190353	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
EDCC5055_RS11475	2190421..2191203	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T293425 WP_001802298.1 NZ_LT671859:c2186587-2186483 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

Antitoxin

Nucleotide

• Length: 56 bp

>AT293425 NZ_LT671859:2186370-2186425 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin