Detailed information of TA system TA293419

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2009035..2009342
• Replicon: chromosome
• Accession: NZ_LT671859
• Organism: Staphylococcus aureus isolate Clinical isolate

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: EDCC5055_RS10365
• Protein ID: WP_011447039.1
• Coordinates: 2009166..2009342 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2009035..2009174 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EDCC5055_RS10305	2004601..2004780	+	180	WP_000669791.1	hypothetical protein	-
EDCC5055_RS10315	2005091..2005351	+	261	WP_001791826.1	hypothetical protein	-
EDCC5055_RS10320	2005404..2005754	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
EDCC5055_RS10325	2006265..2006600	-	336	Protein_1892	SH3 domain-containing protein	-
EDCC5055_RS10345	2007251..2007742	-	492	WP_000920038.1	staphylokinase	-
EDCC5055_RS10350	2007933..2008688	-	756	WP_000861038.1	CHAP domain-containing protein	-
EDCC5055_RS10355	2008700..2008954	-	255	WP_000611508.1	phage holin	-
EDCC5055_RS10360	2009006..2009113	+	108	WP_031762631.1	hypothetical protein	-
-	2009035..2009174	+	140	NuclAT_0	-	Antitoxin
-	2009035..2009174	+	140	NuclAT_0	-	Antitoxin
-	2009035..2009174	+	140	NuclAT_0	-	Antitoxin
-	2009035..2009174	+	140	NuclAT_0	-	Antitoxin
EDCC5055_RS10365	2009166..2009342	-	177	WP_011447039.1	putative holin-like toxin	Toxin
EDCC5055_RS10370	2009451..2010224	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
EDCC5055_RS10375	2010597..2010971	-	375	WP_000340977.1	hypothetical protein	-
EDCC5055_RS10380	2011027..2011314	-	288	WP_001262621.1	hypothetical protein	-
EDCC5055_RS10385	2011360..2011512	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2005404..2063165	57761

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T293419 WP_011447039.1 NZ_LT671859:c2009342-2009166 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT293419 NZ_LT671859:2009035-2009174 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin