293409

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2750754..2751997 Replicon chromosome
Accession NZ_LT632616
Organism Legionella pneumophila strain ST37 isolate ST37

Toxin (Protein)


Gene name HipT Uniprot ID Q5ZSZ6
Locus tag H044120014_RS12490 Protein ID WP_010948074.1
Coordinates 2751059..2751997 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q5ZSZ7
Locus tag H044120014_RS12485 Protein ID WP_010948073.1
Coordinates 2750754..2751062 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H044120014_RS12460 2746190..2746555 + 366 WP_010948069.1 BRCT domain-containing protein -
H044120014_RS12465 2746912..2747277 - 366 WP_010948070.1 TraK family protein -
H044120014_RS15935 2747462..2747602 - 141 WP_153802426.1 hypothetical protein -
H044120014_RS12470 2747605..2749356 - 1752 WP_010948071.1 DUF927 domain-containing protein -
H044120014_RS12475 2749422..2749697 - 276 WP_010948072.1 helix-turn-helix domain-containing protein -
H044120014_RS12480 2750530..2750757 + 228 WP_006870829.1 helix-turn-helix transcriptional regulator -
H044120014_RS12485 2750754..2751062 + 309 WP_010948073.1 HipA N-terminal domain-containing protein Antitoxin
H044120014_RS12490 2751059..2751997 + 939 WP_010948074.1 lpg2370 family Dot/Icm T4SS effector Toxin
H044120014_RS12500 2752540..2753154 + 615 WP_010948075.1 hypothetical protein -
H044120014_RS12505 2753310..2753516 - 207 WP_015444115.1 hypothetical protein -
H044120014_RS12510 2753853..2755121 + 1269 WP_010948076.1 lpg2372 family Dot/Icm T4SS effector -
H044120014_RS12515 2755337..2755862 - 526 Protein_2411 hypothetical protein -
H044120014_RS12520 2755862..2756527 - 666 WP_015444114.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2744776..2745951 1175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36077.81 Da        Isoelectric Point: 8.6882

>T293409 WP_010948074.1 NZ_LT632616:2751059-2751997 [Legionella pneumophila]
MKHCPITYEKISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQEMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11557.38 Da        Isoelectric Point: 4.5994

>AT293409 WP_010948073.1 NZ_LT632616:2750754-2751062 [Legionella pneumophila]
MRKAYVSVSGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEEIR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VKC
PDB 7VKB
PDB 7WCF

Antitoxin

Source ID Structure
PDB 7VKB
AlphaFold DB Q5ZSZ7

References